| Tag |
Content |
| dbPAF ID |
dbPAF-0000057 |
| Uniprot Accession |
O00292; LFTY2_HUMAN; B3KNH4; B4E332; E9PDM4; O75611; Q5TE89; Q8NBQ9;
|
| Genbank Protein ID |
NP_001165896.1; NP_003231.2;
|
| Genbank Nucleotide ID |
NM_001172425.1; NM_003240.3;
|
| Protein Name |
Left-right determination factor 2 |
| Protein Synonyms/Alias |
Endometrial bleeding-associated factor;Left-right determination factor A;Protein lefty-2;Protein lefty-A;Transforming growth factor beta-4;TGF-beta-4; |
| Gene Name |
LEFTY2 |
| Gene Synonyms/Alias |
EBAF;LEFTA;LEFTYA;TGFB4;PSEC0024; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.Functional Description
Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding. |
Phosphorylation Sites
|
dbPAF PTMs: 1 |
Sequence
(Fasta) | MWPLWLCWAL WVLPLAGPGA ALTEEQLLGS LLRQLQLSEV PVLDRADMEK LVIPAHVRAQ 60
YVVLLRRSHG DRSRGKRFSQ SFREVAGRFL ASEASTHLLV FGMEQRLPPN SELVQAVLRL 120
FQEPVPKAAL HRHGRLSPRS AQARVTVEWL RVRDDGSNRT SLIDSRLVSV HESGWKAFDV 180
TEAVNFWQQL SRPRQPLLLQ VSVQREHLGP LASGAHKLVR FASQGAPAGL GEPQLELHTL 240
DLRDYGAQGD CDPEAPMTEG TRCCRQEMYI DLQGMKWAKN WVLEPPGFLA YECVGTCQQP 300
PEALAFNWPF LGPRQCIASE TASLPMIVSI KEGGRTRPQV VSLPNMRVQK CSCASDGALV 360
PRRLQP
367Fasta Sequence
>O00292|LEFTY2|Homo sapiens(Human)
MWPLWLCWALWVLPLAGPGAALTEEQLLGSLLRQLQLSEVPVLDRADMEKLVIPAHVRAQYVVLLRRSHGDRSRGKRFSQSFREVAGRFLASEASTHLLVFGMEQRLPPNSELVQAVLRLFQEPVPKAALHRHGRLSPRSAQARVTVEWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHKLVRFASQGAPAGLGEPQLELHTLDLRDYGAQGDCDPEAPMTEGTRCCRQEMYIDLQGMKWAKNWVLEPPGFLAYECVGTCQQPPEALAFNWPFLGPRQCIASETASLPMIVSIKEGGRTRPQVVSLPNMRVQKCSCASDGALVPRRLQP
|
| Keyword |
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0202--Cytokine
KW-0217--Developmental protein
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0339--Growth factor
KW-1056--Heterotaxy
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
|
| Interpro |
IPR029034--Cystine-knot_cytokine
IPR003942--LRDF
IPR001839--TGF-b_C
IPR001111--TGF-b_N
IPR015615--TGF-beta-rel
IPR017948--TGFb_CS
|
| PROSITE |
PS00250--TGF_BETA_1
PS51362--TGF_BETA_2
|
| Pfam |
PF00019--TGF_beta
PF00688--TGFb_propeptide
|
| Gene Ontology |
GO:0031012--C:extracellular matrix
GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0031093--C:platelet alpha granule lumen
GO:0005125--F:cytokine activity
GO:0005160--F:transforming growth factor beta receptor binding
GO:0007596--P:blood coagulation
GO:0048468--P:cell development
GO:0016049--P:cell growth
GO:0007275--P:multicellular organismal development
GO:0030168--P:platelet activation
GO:0002576--P:platelet degranulation
GO:0010862--P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0042981--P:regulation of apoptotic process
GO:0043408--P:regulation of MAPK cascade
GO:0060395--P:SMAD protein signal transduction
GO:0007179--P:transforming growth factor beta receptor signaling pathway
|
