dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000056
Uniprot Accession O00291; HIP1_HUMAN; B4E3I7; E7ES17; O00328; Q2TB58; Q8TDL4; V5LU97;
Genbank Protein ID NP_001230127.1; NP_005329.3; XP_005250361.1; XP_011514418.1;
Genbank Nucleotide ID NM_001243198.2; NM_005338.6; XM_005250304.2; XM_011516116.1;
Protein Name Huntingtin-interacting protein 1
Protein Synonyms/Alias
Gene Name HIP1
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
Phosphorylation Sites
 dbPAF PTMs: 15
PositionPeptidesSourceReferences ( PMIDs )
6--MDRMASSMKQVPNPHOSIDA21081558
7-MDRMASSMKQVPNPcurated26074081
35LEAAERESFERTQTVdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20058876; 16381945; 23193290; 18988627; 22135298; 22817900
114HPNVLKDSLRYRNELcurated20873877
152LLRTKMEYHTKNPRFPhosphoSitePlus22135298
319VVIPAEASSPDSEPVcurated25627689
320VIPAEASSPDSEPVLdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 25850435;
323AEASSPDSEPVLEKDdbPTM 3.0;HPRD 9;PHOSIDA;curated20068231; 16381945; 23193290; 18988627; 21081558; 25850435;
338DLMDMDASQQNLFDNPhosphoSitePlus;UniProt;curated22135298; 24275569; 25627689
455EKAQRSLSEIERKAQPhosphoSitePlus;curated22135298; 25627689
516EKKELEDSLERISDQdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 25850435; 22817900
851LQREIVESGRGTASPcurated25627689
857ESGRGTASPKEFYAKPhosphoSitePlus;curated22135298; 25627689
1009GELRKKHYELAGVAEdbPTM 3.0;PhosphoSitePlus;curated20736484; 16381945; 23193290; 22135298; 22817900
1025WEEGTEASPPTLQEVdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298
Sequence
(Fasta)		MDRMASSMKQ VPNPLPKVLS RRGVGAGLEA AERESFERTQ TVSINKAINT QEVAVKEKHA 60
RTCILGTHHE KGAQTFWSVV NRLPLSSNAV LCWKFCHVFH KLLRDGHPNV LKDSLRYRNE 120
LSDMSRMWGH LSEGYGQLCS IYLKLLRTKM EYHTKNPRFP GNLQMSDRQL DEAGESDVNN 180
FFQLTVEMFD YLECELNLFQ TVFNSLDMSR SVSVTAAGQC RLAPLIQVIL DCSHLYDYTV 240
KLLFKLHSCL PADTLQGHRD RFMEQFTKLK DLFYRSSNLQ YFKRLIQIPQ LPENPPNFLR 300
ASALSEHISP VVVIPAEASS PDSEPVLEKD DLMDMDASQQ NLFDNKFDDI FGSSFSSDPF 360
NFNSQNGVNK DEKDHLIERL YREISGLKAQ LENMKTESQR VVLQLKGHVS ELEADLAEQQ 420
HLRQQAADDC EFLRAELDEL RRQREDTEKA QRSLSEIERK AQANEQRYSK LKEKYSELVQ 480
NHADLLRKNA EVTKQVSMAR QAQVDLEREK KELEDSLERI SDQGQRKTQE QLEVLESLKQ 540
ELATSQRELQ VLQGSLETSA QSEANWAAEF AELEKERDSL VSGAAHREEE LSALRKELQD 600
TQLKLASTEE SMCQLAKDQR KMLLVGSRKA AEQVIQDALN QLEEPPLISC AGSADHLLST 660
VTSISSCIEQ LEKSWSQYLA CPEDISGLLH SITLLAHLTS DAIAHGATTC LRAPPEPADS 720
LTEACKQYGR ETLAYLASLE EEGSLENADS TAMRNCLSKI KAIGEELLPR GLDIKQEELG 780
DLVDKEMAAT SAAIETATAR IEEMLSKSRA GDTGVKLEVN ERILGCCTSL MQAIQVLIVA 840
SKDLQREIVE SGRGTASPKE FYAKNSRWTE GLISASKAVG WGATVMVDAA DLVVQGRGKF 900
EELMVCSHEI AASTAQLVAA SKVKADKDSP NLAQLQQASR GVNQATAGVV ASTISGKSQI 960
EETDNMDFSS MTLTQIKRQE MDSQVRVLEL ENELQKERQK LGELRKKHYE LAGVAEGWEE 1020
GTEASPPTLQ EVVTEKE 1038
Keyword

KW-0002--3D-structure
KW-0009--Actin-binding
KW-0010--Activator
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0160--Chromosomal rearrangement
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0221--Differentiation
KW-0254--Endocytosis
KW-0472--Membrane
KW-0523--Neurodegeneration
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR011417--ANTH_dom
IPR013809--ENTH
IPR008942--ENTH_VHS
IPR030554--HIP1
IPR032422--HIP1_clath-bd
IPR002558--ILWEQ_dom
IPR030224--Sla2_fam
PROSITE

PS50942--ENTH
PS50945--I_LWEQ
Pfam

PF07651--ANTH
PF16515--HIP1_clath_bdg
PF01608--I_LWEQ
Gene Ontology

GO:0030136--C:clathrin-coated vesicle
GO:0030665--C:clathrin-coated vesicle membrane
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005794--C:Golgi apparatus
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0030276--F:clathrin binding
GO:0035091--F:phosphatidylinositol binding
GO:0005200--F:structural constituent of cytoskeleton
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915--P:apoptotic process
GO:0097190--P:apoptotic signaling pathway
GO:0030154--P:cell differentiation
GO:0048268--P:clathrin coat assembly
GO:0072583--P:clathrin-mediated endocytosis
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0042981--P:regulation of apoptotic process
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated