dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000054
Uniprot Accession O00273; DFFA_HUMAN; Q5T6G5; Q5T6G6; Q96I97; Q9Y6C6;
Genbank Protein ID NP_004392.1; NP_998731.1;
Genbank Nucleotide ID NM_004401.2; NM_213566.1;
Protein Name DNA fragmentation factor subunit alpha
Protein Synonyms/Alias DNA fragmentation factor 45 kDa subunit;DFF-45;Inhibitor of CAD;ICAD;
Gene Name DFFA
Gene Synonyms/Alias DFF1;DFF45;H13;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Inhibitor of the caspase-activated DNase (DFF40).
Phosphorylation Sites
 dbPAF PTMs: 16
PositionPeptidesSourceReferences ( PMIDs )
27PCLLRRNYSREQHGVcurated23911959
28CLLRRNYSREQHGVAdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20166139; 20230923; 16381945; 23193290; 18988627; 22135298;
75TIVDDDDYFLCLPSNPhosphoSitePlus;curated22135298; 22817900
107DGGTAWISQESFDVDdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated18077418; 21659604; 16381945; 23193290; 18988627; 22135298;
110TAWISQESFDVDETDdbPTM 3.0;PhosphoSitePlus;curated21659604; 16381945; 23193290; 22135298; 25627689; 26074081
231DTGISRETSSDVALAcurated25003641
232TGISRETSSDVALASPhosphoSitePlus;curated22135298; 25627689; 23186163; 24117733
233GISRETSSDVALASHPhosphoSitePlus;curated22135298; 25627689; 23403867
239SSDVALASHILTALRcurated23403867
243ALASHILTALREKQAPhosphoSitePlus;curated22135298; 23186163
254EKQAPELSLSSQDLEdbPTM 3.0;curated20068231; 16381945; 23193290; 25627689
256QAPELSLSSQDLELVdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627; 25627689
257APELSLSSQDLELVTdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated17525332; 16381945; 23193290; 18077418; 20068231; 19413330;
310LHSLRSISASKASPPdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated18187866; 16381945; 23193290; 20068231; 18988627; 22135298;
312SLRSISASKASPPGDdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 23911959
315SISASKASPPGDLQNdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated16964243; 17924679; 18187866; 18669648; 19413330; 16381945;
Sequence
(Fasta)		MEVTGDAGVP ESGEIRTLKP CLLRRNYSRE QHGVAASCLE DLRSKACDIL AIDKSLTPVT 60
LVLAEDGTIV DDDDYFLCLP SNTKFVALAS NEKWAYNNSD GGTAWISQES FDVDETDSGA 120
GLKWKNVARQ LKEDLSSIIL LSEEDLQMLV DAPCSDLAQE LRQSCATVQR LQHTLQQVLD 180
QREEVRQSKQ LLQLYLQALE KEGSLLSKQE ESKAAFGEEV DAVDTGISRE TSSDVALASH 240
ILTALREKQA PELSLSSQDL ELVTKEDPKA LAVALNWDIK KTETVQEACE RELALRLQQT 300
QSLHSLRSIS ASKASPPGDL QNPKRARQDP T 332
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR003508--CIDE-N_dom
IPR027296--DFF-C_dom
IPR017299--DNA_fragmentation_factor_asu
IPR015121--DNA_fragmentation_mid_dom
PROSITE

PS51135--CIDE_N
Pfam

PF02017--CIDE-N
PF09033--DFF-C
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0006309--P:apoptotic DNA fragmentation
GO:0006915--P:apoptotic process
GO:0006921--P:cellular component disassembly involved in execution phase of apoptosis
GO:1902511--P:negative regulation of apoptotic DNA fragmentation
GO:1900118--P:negative regulation of execution phase of apoptosis
GO:0043065--P:positive regulation of apoptotic process
GO:0012501--P:programmed cell death
GO:0070242--P:thymocyte apoptotic process