dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000053
Uniprot Accession O00268; TAF4_HUMAN; A6NGD9; Q5TBP6; Q99721; Q9BR40; Q9BX42;
Genbank Protein ID NP_003176.2;
Genbank Nucleotide ID NM_003185.3;
Protein Name Transcription initiation factor TFIID subunit 4
Protein Synonyms/Alias RNA polymerase II TBP-associated factor subunit C;TBP-associated factor 4;Transcription initiation factor TFIID 130 kDa subunit;TAF(II)130;TAFII-130;TAFII130;Transcription initiation factor TFIID 135 kDa subunit;TAF(II)135;TAFII-135;TAFII135;
Gene Name TAF4
Gene Synonyms/Alias TAF2C;TAF2C1;TAF4A;TAFII130;TAFII135;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone.
Phosphorylation Sites
 dbPAF PTMs: 24 (View all)
PositionPeptidesSourceReferences ( PMIDs )
23EVDEKVVSDLVGSLEPhosphoSitePlus22135298
47HHHLAPRTPEVRAAAPhosphoSitePlus;curated22135298; 26074081
109PQRPGPPSPRRPLVPPhosphoSitePlus;curated22135298; 23917254; 24961811
409KGAAGAVTQSLSRTPPhosphoSitePlus22135298
411AAGAVTQSLSRTPTAPhosphoSitePlus22135298
415VTQSLSRTPTATTSGPhosphoSitePlus22135298
421RTPTATTSGIRATLTPhosphoSitePlus22135298
528TTIIKQVSQAQTTVQPhosphoSitePlus22135298
543PSATLQRSPGVQPQLdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated19690332; 16381945; 23193290; 19060867; 22135298; 25850435;
571ATAVQTGTPQRTVPGPhosphoSitePlus22135298
582TVPGATTTSSAATETcurated24667141
583VPGATTTSSAATETMcurated24667141
601KKCKNFLSTLIKLASdbPTM 3.018785766; 16381945; 23193290
608STLIKLASSGKQSTEdbPTM 3.018785766; 16381945; 23193290
648LYRELNSSPQPYLVPPhosphoSitePlus;curated22135298; 23917254
652LNSSPQPYLVPFLKRPhosphoSitePlus22135298
827LKEPGGGSFRDDDDIdbPTM 3.0;PhosphoSitePlus;curated22115753; 16381945; 23193290; 22135298
857ARILATNSELVGTLTdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298
862TNSELVGTLTRSCKDdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
1027VDCPGPGSGAEGSGPcurated25850435
Sequence
(Fasta)		MAAGSDLLDE VFFNSEVDEK VVSDLVGSLE SQLAASAAHH HHLAPRTPEV RAAAAGALGN 60
HVVSGSPAGA AGAGPAAPAE GAPGAAPEPP PAGRARPGGG GPQRPGPPSP RRPLVPAGPA 120
PPAAKLRPPP EGSAGSCAPV PAAAAVAAGP EPAPAGPAKP AGPAALAARA GPGPGPGPGP 180
GPGPGPGKPA GPGAAQTLNG SAALLNSHHA AAPAVSLVNN GPAALLPLPK PAAPGTVIQT 240
PPFVGAAAPP APAAPSPPAA PAPAAPAAAP PPPPPAPATL ARPPGHPAGP PTAAPAVPPP 300
AAAQNGGSAG AAPAPAPAAG GPAGVSGQPG PGAAAAAPAP GVKAESPKRV VQAAPPAAQT 360
LAASGPASTA ASMVIGPTMQ GALPSPAAVP PPAPGTPTGL PKGAAGAVTQ SLSRTPTATT 420
SGIRATLTPT VLAPRLPQPP QNPTNIQNFQ LPPGMVLVRS ENGQLLMIPQ QALAQMQAQA 480
HAQPQTTMAP RPATPTSAPP VQISTVQAPG TPIIARQVTP TTIIKQVSQA QTTVQPSATL 540
QRSPGVQPQL VLGGAAQTAS LGTATAVQTG TPQRTVPGAT TTSSAATETM ENVKKCKNFL 600
STLIKLASSG KQSTETAANV KELVQNLLDG KIEAEDFTSR LYRELNSSPQ PYLVPFLKRS 660
LPALRQLTPD SAAFIQQSQQ QPPPPTSQAT TALTAVVLSS SVQRTAGKTA ATVTSALQPP 720
VLSLTQPTQV GVGKQGQPTP LVIQQPPKPG ALIRPPQVTL TQTPMVALRQ PHNRIMLTTP 780
QQIQLNPLQP VPVVKPAVLP GTKALSAVSA QAAAAQKNKL KEPGGGSFRD DDDINDVASM 840
AGVNLSEESA RILATNSELV GTLTRSCKDE TFLLQAPLQR RILEIGKKHG ITELHPDVVS 900
YVSHATQQRL QNLVEKISET AQQKNFSYKD DDRYEQASDV RAQLKFFEQL DQIEKQRKDE 960
QEREILMRAA KSRSRQEDPE QLRLKQKAKE MQQQELAQMR QRDANLTALA AIGPRKKRKV 1020
DCPGPGSGAE GSGPGSVVPG SSGVGTPRQF TRQRITRVNL RDLIFCLENE RETSHSLLLY 1080
KAFLK 1086
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0945--Host-virus interaction
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR009072--Histone-fold
IPR007900--TAF4
IPR003894--TAFH_NHR1
PROSITE

PS51119--TAFH
Pfam

PF05236--TAF4
PF07531--TAFH
Gene Ontology

GO:0005737--C:cytoplasm
GO:0071339--C:MLL1 complex
GO:0005654--C:nucleoplasm
GO:0005669--C:transcription factor TFIID complex
GO:0033276--C:transcription factor TFTC complex
GO:0003677--F:DNA binding
GO:0003713--F:transcription coactivator activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0006352--P:DNA-templated transcription, initiation
GO:0010467--P:gene expression
GO:0001541--P:ovarian follicle development
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0006367--P:transcription initiation from RNA polymerase II promoter
GO:0016032--P:viral process