dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000048
Uniprot Accession O00255; MEN1_HUMAN; A5HBC6; A5HBC7; A5HBC8; A5HBC9; A5HBD0; A5HBD1; A5HBD2; O00632; Q9BUF0; Q9BUK2;
Genbank Protein ID NP_000235.2; NP_570711.1; NP_570712.1; NP_570713.1; NP_570714.1; NP_570715.1; NP_570716.1; XP_005274058.1;
Genbank Nucleotide ID NM_000244.3; NM_130799.2; NM_130800.2; NM_130801.2; NM_130802.2; NM_130803.2; NM_130804.2; XM_005274001.3;
Protein Name Menin
Protein Synonyms/Alias
Gene Name MEN1
Gene Synonyms/Alias SCG2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.
Phosphorylation Sites
 dbPAF PTMs: 11
PositionPeptidesSourceReferences ( PMIDs )
399EERPGEQSQGTQSQGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated17525332; 16381945; 23193290; 18077418; 18988627; 22135298;
402PGEQSQGTQSQGSALPhosphoSitePlus22135298
404EQSQGTQSQGSALQDPhosphoSitePlus22135298
443VLHVGWATFLVQSLGPhosphoSitePlus22135298
448WATFLVQSLGRFEGQPhosphoSitePlus22135298
492RRGPRRESKPEEPPPdbPTM 3.0;HPRD 9;PhosphoSitePlus;UniProt;curated20068231; 16381945; 23193290; 18988627; 22135298; 24275569;
548QVPAPTASPPPEGPVdbPTM 3.0;PhosphoSitePlus;curated19413330; 19690332; 16381945; 23193290; 19664995; 22135298;
560GPVLTFQSEKMKGMKcurated19690332
588KLQLTAQSQVQMKKQPhosphoSitePlus22135298
598QMKKQKVSTPSDYTLdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627; 25627689; 22199227
599MKKQKVSTPSDYTLSdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 18988627; 22135298; 19366988;
Sequence
(Fasta)		MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV NRVIPTNVPE 60
LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA VDLSLYPREG GVSSRELVKK 120
VSDVIWNSLS RSYFKDRAHI QSLFSFITGW SPVGTKLDSS GVAFAVVGAC QALGLRDVHL 180
ALSEDHAWVV FGPNGEQTAE VTWHGKGNED RRGQTVNAGV AERSWLYLKG SYMRCDRKME 240
VAFMVCAINP SIDLHTDSLE LLQLQQKLLW LLYDLGHLER YPMALGNLAD LEELEPTPGR 300
PDPLTLYHKG IASAKTYYRD EHIYPYMYLA GYHCRNRNVR EALQAWADTA TVIQDYNYCR 360
EDEEIYKEFF EVANDVIPNL LKEAASLLEA GEERPGEQSQ GTQSQGSALQ DPECFAHLLR 420
FYDGICKWEE GSPTPVLHVG WATFLVQSLG RFEGQVRQKV RIVSREAEAA EAEEPWGEEA 480
REGRRRGPRR ESKPEEPPPP KKPALDKGLG TGQGAVSGPP RKPPGTVAGT ARGPEGGSTA 540
QVPAPTASPP PEGPVLTFQS EKMKGMKELL VATKINSSAI KLQLTAQSQV QMKKQKVSTP 600
SDYTLSFLKR QRKGL 616
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR007747--Menin
PROSITE
Pfam

PF05053--Menin
Gene Ontology

GO:0000785--C:chromatin
GO:0032154--C:cleavage furrow
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0035097--C:histone methyltransferase complex
GO:0016363--C:nuclear matrix
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0003682--F:chromatin binding
GO:0003690--F:double-stranded DNA binding
GO:0000400--F:four-way junction DNA binding
GO:0030674--F:protein binding, bridging
GO:0047485--F:protein N-terminus binding
GO:0070412--F:R-SMAD binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0000403--F:Y-form DNA binding
GO:0007420--P:brain development
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071333--P:cellular response to glucose stimulus
GO:0071375--P:cellular response to peptide hormone stimulus
GO:0046697--P:decidualization
GO:0006281--P:DNA repair
GO:0010467--P:gene expression
GO:0034968--P:histone lysine methylation
GO:0000165--P:MAPK cascade
GO:0000278--P:mitotic cell cycle
GO:0045786--P:negative regulation of cell cycle
GO:1902807--P:negative regulation of cell cycle G1/S phase transition
GO:0008285--P:negative regulation of cell proliferation
GO:0010812--P:negative regulation of cell-substrate adhesion
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0050680--P:negative regulation of epithelial cell proliferation
GO:0046329--P:negative regulation of JNK cascade
GO:0045668--P:negative regulation of osteoblast differentiation
GO:0001933--P:negative regulation of protein phosphorylation
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0051974--P:negative regulation of telomerase activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0002076--P:osteoblast development
GO:0032092--P:positive regulation of protein binding
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032925--P:regulation of activin receptor signaling pathway
GO:0061469--P:regulation of type B pancreatic cell proliferation
GO:0010332--P:response to gamma radiation
GO:0009411--P:response to UV
GO:0007264--P:small GTPase mediated signal transduction
GO:0006367--P:transcription initiation from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0003309--P:type B pancreatic cell differentiation