| Tag |
Content |
| dbPAF ID |
dbPAF-0000044 |
| Uniprot Accession |
O00238; BMR1B_HUMAN; B2R953; B4DSV1; P78366;
|
| Genbank Protein ID |
NP_001194.1; NP_001243721.1; NP_001243722.1; NP_001243723.1; XP_011530503.1; XP_011530504.1;
|
| Genbank Nucleotide ID |
NM_001203.2; NM_001256792.1; NM_001256793.1; NM_001256794.1; XM_011532201.1; XM_011532202.1;
|
| Protein Name |
Bone morphogenetic protein receptor type-1B |
| Protein Synonyms/Alias |
|
| Gene Name |
BMPR1B |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction (By similarity).Functional Description
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MLLRSAGKLN VGTKKEDGES TAPTPRPKVL RCKCHHHCPE DSVNNICSTD GYCFTMIEED 60
DSGLPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKNRDFVD 120
GPIHHRALLI SVTVCSLLLV LIILFCYFRY KRQETRPRYS IGLEQDETYI PPGESLRDLI 180
EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS 240
WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDAKS 300
MLKLAYSSVS GLCHLHTEIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVKFISD 360
TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM YSFGLILWEV ARRCVSGGIV 420
EEYQLPYHDL VPSDPSYEDM REIVCIKKLR PSFPNRWSSD ECLRQMGKLM TECWAHNPAS 480
RLTALRVKKT LAKMSESQDI KL
503Fasta Sequence
>O00238|BMPR1B|Homo sapiens(Human)
MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0891--Chondrogenesis
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0242--Dwarfism
KW-0418--Kinase
KW-0460--Magnesium
KW-0464--Manganese
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR000472--Activin_recp
IPR003605--GS_dom
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008271--Ser/Thr_kinase_AS
IPR000333--TGFB_receptor
|
| PROSITE |
PS51256--GS
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
|
| Pfam |
PF01064--Activin_recp
PF07714--Pkinase_Tyr
PF08515--TGF_beta_GS
|
| Gene Ontology |
GO:0030425--C:dendrite
GO:1990712--C:HFE-transferrin receptor complex
GO:0005887--C:integral component of plasma membrane
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0043235--C:receptor complex
GO:0005524--F:ATP binding
GO:0001948--F:glycoprotein binding
GO:0046872--F:metal ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0004702--F:receptor signaling protein serine/threonine kinase activity
GO:0046332--F:SMAD binding
GO:0005025--F:transforming growth factor beta receptor activity, type I
GO:0004675--F:transmembrane receptor protein serine/threonine kinase activity
GO:0030509--P:BMP signaling pathway
GO:0001502--P:cartilage condensation
GO:0071773--P:cellular response to BMP stimulus
GO:0002063--P:chondrocyte development
GO:0009953--P:dorsal/ventral pattern formation
GO:0060350--P:endochondral bone morphogenesis
GO:0001654--P:eye development
GO:0006954--P:inflammatory response
GO:0035108--P:limb morphogenesis
GO:1902731--P:negative regulation of chondrocyte proliferation
GO:0001550--P:ovarian cumulus expansion
GO:0042698--P:ovulation cycle
GO:0030501--P:positive regulation of bone mineralization
GO:0061036--P:positive regulation of cartilage development
GO:0045597--P:positive regulation of cell differentiation
GO:1902043--P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045669--P:positive regulation of osteoblast differentiation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006468--P:protein phosphorylation
GO:0030166--P:proteoglycan biosynthetic process
GO:0060041--P:retina development in camera-type eye
GO:0031290--P:retinal ganglion cell axon guidance
GO:0001501--P:skeletal system development
|
