dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000042
Uniprot Accession O00233; PSMD9_HUMAN; B2RD35; G3V1Q6; Q9BQ42;
Genbank Protein ID NP_001248329.1; NP_002804.2;
Genbank Nucleotide ID NM_001261400.2; NM_002813.6;
Protein Name 26S proteasome non-ATPase regulatory subunit 9
Protein Synonyms/Alias 26S proteasome regulatory subunit p27;
Gene Name PSMD9
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
2------MSDEEARQSdbPTM 3.0;PhosphoSitePlus;curated22115753; 16381945; 23193290; 22135298; 25627689; 20068231
13ARQSGGSSQAGVVTVPhosphoSitePlus22135298
41EAQIKANYDVLESQKdbPTM 3.0;PhosphoSitePlus;curated18180459; 16381945; 23193290; 22135298; 22817900
62PLVDCEGYPRSDVDLPhosphoSitePlus22135298
65DCEGYPRSDVDLYQVPhosphoSitePlus22135298
70PRSDVDLYQVRTARHPhosphoSitePlus;curated22135298; 22817900
121EAHKEAMSRKLGQSEdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
127MSRKLGQSESQGPPRPhosphoSitePlus;curated22135298; 25627689
129RKLGQSESQGPPRAFPhosphoPep 2.0;PhosphoSitePlus;curated19060867; 22135298; 22817900
Sequence
(Fasta)		MSDEEARQSG GSSQAGVVTV SDVQELMRRK EEIEAQIKAN YDVLESQKGI GMNEPLVDCE 60
GYPRSDVDLY QVRTARHNII CLQNDHKAVM KQVEEALHQL HARDKEKQAR DMAEAHKEAM 120
SRKLGQSESQ GPPRAFAKVN SISPGSPASI AGLQVDDEIV EFGSVNTQNF QSLHNIGSVV 180
QHSEGKPLNV TVIRRGEKHQ LRLVPTRWAG KGLLGCNIIP LQR 224
Keyword

KW-0025--Alternative splicing
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR001478--PDZ
PROSITE
Pfam

PF13180--PDZ_2
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005838--C:proteasome regulatory particle
GO:0043425--F:bHLH transcription factor binding
GO:0003713--F:transcription coactivator activity
GO:0000186--P:activation of MAPKK activity
GO:0031145--P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0042590--P:antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0002479--P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002474--P:antigen processing and presentation of peptide antigen via MHC class I
GO:0006915--P:apoptotic process
GO:0007411--P:axon guidance
GO:0034641--P:cellular nitrogen compound metabolic process
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0010467--P:gene expression
GO:0045087--P:innate immune response
GO:0008286--P:insulin receptor signaling pathway
GO:0000165--P:MAPK cascade
GO:0000278--P:mitotic cell cycle
GO:0043066--P:negative regulation of apoptotic process
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0046676--P:negative regulation of insulin secretion
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0038061--P:NIK/NF-kappaB signaling
GO:0006595--P:polyamine metabolic process
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0032024--P:positive regulation of insulin secretion
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0012501--P:programmed cell death
GO:0070682--P:proteasome regulatory particle assembly
GO:0000209--P:protein polyubiquitination
GO:0007265--P:Ras protein signal transduction
GO:0042981--P:regulation of apoptotic process
GO:0006521--P:regulation of cellular amino acid metabolic process
GO:0043488--P:regulation of mRNA stability
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0007264--P:small GTPase mediated signal transduction
GO:0044281--P:small molecule metabolic process
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0050852--P:T cell receptor signaling pathway
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway
GO:0016032--P:viral process