dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0000041
Uniprot Accession O00232; PSD12_HUMAN; A6NP15; Q53HA2; Q6P053;
Genbank Protein ID NP_002807.1; NP_777360.1; XP_011523350.1; XP_011523351.1;
Genbank Nucleotide ID NM_002816.4; NM_174871.3; XM_011525048.1; XM_011525049.1;
Protein Name 26S proteasome non-ATPase regulatory subunit 12
Protein Synonyms/Alias 26S proteasome regulatory subunit RPN5;26S proteasome regulatory subunit p55;
Gene Name PSMD12
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Phosphorylation Sites
dbPAF PTMs: 17
PositionPeptidesSourceReferences ( PMIDs )
20IVKMEVDYSATVDQRPhosphoSitePlus22135298
56SLEKQTRTASDMVSTPHOSIDA21081558
58EKQTRTASDMVSTSRPHOSIDA21081558
62RTASDMVSTSRILVAPHOSIDA21081558
111MVQQCCTYVEEITDLPhosphoSitePlus22135298
137MVTEGKIYVEIERARdbPTM 3.0;PhosphoSitePlus20393185; 16381945; 23193290; 22135298
219KFFQEENTEKLKLKYPhosphoSitePlus22135298
227EKLKLKYYNLMIQLDdbPTM 3.0;HPRD 918452278; 16381945; 23193290; 18988627
251CKHYRAIYDTPCIQAPHOSIDA21081558
253HYRAIYDTPCIQAESPHOSIDA21081558
332GMELRKGSLESPATDcurated25850435
335LRKGSLESPATDVFGPhosphoSitePlus;curated22135298; 25627689
338GSLESPATDVFGSTEcurated25850435
369NIRIMAKYYTRITMKPhosphoSitePlus22135298
370IRIMAKYYTRITMKRPhosphoSitePlus22135298
434DWSQKLNSLMSLVNKPhosphoSitePlus;curated22135298; 24961811
437QKLNSLMSLVNKTTHPhosphoSitePlus;curated22135298; 24961811
Sequence
(Fasta)
MADGGSERAD GRIVKMEVDY SATVDQRLPE CAKLAKEGRL QEVIETLLSL EKQTRTASDM 60
VSTSRILVAV VKMCYEAKEW DLLNENIMLL SKRRSQLKQA VAKMVQQCCT YVEEITDLPI 120
KLRLIDTLRM VTEGKIYVEI ERARLTKTLA TIKEQNGDVK EAASILQELQ VETYGSMEKK 180
ERVEFILEQM RLCLAVKDYI RTQIISKKIN TKFFQEENTE KLKLKYYNLM IQLDQHEGSY 240
LSICKHYRAI YDTPCIQAES EKWQQALKSV VLYVILAPFD NEQSDLVHRI SGDKKLEEIP 300
KYKDLLKLFT TMELMRWSTL VEDYGMELRK GSLESPATDV FGSTEEGEKR WKDLKNRVVE 360
HNIRIMAKYY TRITMKRMAQ LLDLSVDESE AFLSNLVVNK TIFAKVDRLA GIINFQRPKD 420
PNNLLNDWSQ KLNSLMSLVN KTTHLIAKEE MIHNLQ 457
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0621--Polymorphism
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0832--Ubl conjugation

Interpro

IPR000717--PCI_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE
Pfam

PF01399--PCI

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0031595--C:nuclear proteasome complex
GO:0005654--C:nucleoplasm
GO:0022624--C:proteasome accessory complex
GO:0000502--C:proteasome complex
GO:0005838--C:proteasome regulatory particle
GO:0008541--C:proteasome regulatory particle, lid subcomplex
GO:0000186--P:activation of MAPKK activity
GO:0031145--P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0042590--P:antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0002479--P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002474--P:antigen processing and presentation of peptide antigen via MHC class I
GO:0006915--P:apoptotic process
GO:0007411--P:axon guidance
GO:0034641--P:cellular nitrogen compound metabolic process
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0010467--P:gene expression
GO:0045087--P:innate immune response
GO:0008286--P:insulin receptor signaling pathway
GO:0000165--P:MAPK cascade
GO:0000278--P:mitotic cell cycle
GO:0043066--P:negative regulation of apoptotic process
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0038061--P:NIK/NF-kappaB signaling
GO:0006595--P:polyamine metabolic process
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0012501--P:programmed cell death
GO:0000209--P:protein polyubiquitination
GO:0007265--P:Ras protein signal transduction
GO:0042981--P:regulation of apoptotic process
GO:0006521--P:regulation of cellular amino acid metabolic process
GO:0043488--P:regulation of mRNA stability
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0007264--P:small GTPase mediated signal transduction
GO:0044281--P:small molecule metabolic process
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0050852--P:T cell receptor signaling pathway
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway
GO:0016032--P:viral process