Tag |
Content |
dbPAF ID |
dbPAF-0000041 |
Uniprot Accession |
O00232; PSD12_HUMAN; A6NP15; Q53HA2; Q6P053; |
Genbank Protein ID |
NP_002807.1; NP_777360.1; XP_011523350.1; XP_011523351.1; |
Genbank Nucleotide ID |
NM_002816.4; NM_174871.3; XM_011525048.1; XM_011525049.1; |
Protein Name |
26S proteasome non-ATPase regulatory subunit 12 |
Protein Synonyms/Alias |
26S proteasome regulatory subunit RPN5;26S proteasome regulatory subunit p55; |
Gene Name |
PSMD12 |
Gene Synonyms/Alias |
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Organism |
Homo sapiens(Human) |
NCBI Taxa ID |
9606 |
Functional Description (View all) |
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.Functional Description
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
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Phosphorylation Sites
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dbPAF PTMs: 17 |
Sequence (Fasta) | MADGGSERAD GRIVKMEVDY SATVDQRLPE CAKLAKEGRL QEVIETLLSL EKQTRTASDM 60 VSTSRILVAV VKMCYEAKEW DLLNENIMLL SKRRSQLKQA VAKMVQQCCT YVEEITDLPI 120 KLRLIDTLRM VTEGKIYVEI ERARLTKTLA TIKEQNGDVK EAASILQELQ VETYGSMEKK 180 ERVEFILEQM RLCLAVKDYI RTQIISKKIN TKFFQEENTE KLKLKYYNLM IQLDQHEGSY 240 LSICKHYRAI YDTPCIQAES EKWQQALKSV VLYVILAPFD NEQSDLVHRI SGDKKLEEIP 300 KYKDLLKLFT TMELMRWSTL VEDYGMELRK GSLESPATDV FGSTEEGEKR WKDLKNRVVE 360 HNIRIMAKYY TRITMKRMAQ LLDLSVDESE AFLSNLVVNK TIFAKVDRLA GIINFQRPKD 420 PNNLLNDWSQ KLNSLMSLVN KTTHLIAKEE MIHNLQ
457Fasta Sequence
>O00232|PSMD12|Homo sapiens(Human) MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ
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Keyword |
KW-0007--Acetylation KW-0025--Alternative splicing KW-0181--Complete proteome KW-0903--Direct protein sequencing KW-1017--Isopeptide bond KW-0621--Polymorphism KW-0647--Proteasome KW-1185--Reference proteome KW-0832--Ubl conjugation
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Interpro |
IPR000717--PCI_dom IPR011991--WHTH_DNA-bd_dom
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PROSITE |
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Pfam |
PF01399--PCI
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Gene Ontology |
GO:0005829--C:cytosol GO:0070062--C:extracellular exosome GO:0016020--C:membrane GO:0031595--C:nuclear proteasome complex GO:0005654--C:nucleoplasm GO:0022624--C:proteasome accessory complex GO:0000502--C:proteasome complex GO:0005838--C:proteasome regulatory particle GO:0008541--C:proteasome regulatory particle, lid subcomplex GO:0000186--P:activation of MAPKK activity GO:0031145--P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0042590--P:antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0002479--P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002474--P:antigen processing and presentation of peptide antigen via MHC class I GO:0006915--P:apoptotic process GO:0007411--P:axon guidance GO:0034641--P:cellular nitrogen compound metabolic process GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0007173--P:epidermal growth factor receptor signaling pathway GO:0038095--P:Fc-epsilon receptor signaling pathway GO:0008543--P:fibroblast growth factor receptor signaling pathway GO:0000082--P:G1/S transition of mitotic cell cycle GO:0010467--P:gene expression GO:0045087--P:innate immune response GO:0008286--P:insulin receptor signaling pathway GO:0000165--P:MAPK cascade GO:0000278--P:mitotic cell cycle GO:0043066--P:negative regulation of apoptotic process GO:0090090--P:negative regulation of canonical Wnt signaling pathway GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0048011--P:neurotrophin TRK receptor signaling pathway GO:0038061--P:NIK/NF-kappaB signaling GO:0006595--P:polyamine metabolic process GO:0090263--P:positive regulation of canonical Wnt signaling pathway GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition GO:0012501--P:programmed cell death GO:0000209--P:protein polyubiquitination GO:0007265--P:Ras protein signal transduction GO:0042981--P:regulation of apoptotic process GO:0006521--P:regulation of cellular amino acid metabolic process GO:0043488--P:regulation of mRNA stability GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0007264--P:small GTPase mediated signal transduction GO:0044281--P:small molecule metabolic process GO:0002223--P:stimulatory C-type lectin receptor signaling pathway GO:0050852--P:T cell receptor signaling pathway GO:0033209--P:tumor necrosis factor-mediated signaling pathway GO:0048010--P:vascular endothelial growth factor receptor signaling pathway GO:0016032--P:viral process
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