dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000040
Uniprot Accession O00231; PSD11_HUMAN; A8K3I7; E1P663; O00495; Q53FT5;
Genbank Protein ID NP_001257411.1; NP_002806.2;
Genbank Nucleotide ID NM_001270482.1; NM_002815.3;
Protein Name 26S proteasome non-ATPase regulatory subunit 11
Protein Synonyms/Alias 26S proteasome regulatory subunit RPN6;26S proteasome regulatory subunit S9;26S proteasome regulatory subunit p44.5;
Gene Name PSMD11
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
Phosphorylation Sites
 dbPAF PTMs: 22 (View all)
PositionPeptidesSourceReferences ( PMIDs )
14VEFQRAQSLLSTDREdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17323924; 18669648; 19690332; 16381945; 23193290; 21044959;
17QRAQSLLSTDREASIcurated20873877
23LSTDREASIDILHSIdbPTM 3.0;PhosphoSitePlus;curated21044959; 16381945; 23193290; 22135298; 22115753; 22817900;
49AVQVKEQSILELGSLPhosphoSitePlus22135298
55QSILELGSLLAKTGQPhosphoSitePlus22135298
60LGSLLAKTGQAAELGPhosphoSitePlus22135298
72ELGGLLKYVRPFLNSPhosphoSitePlus22135298
79YVRPFLNSISKAKAAdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated17323924; 16381945; 23193290; 20068231; 18988627; 19060867;
81RPFLNSISKAKAARLdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298
135ALEARLVSLYFDTKRPHOSIDA21081558
137EARLVSLYFDTKRYQPHOSIDA21081558
151QEALHLGSQLLRELKPhosphoSitePlus22135298
201RTTANAIYCPPKLQAPhosphoSitePlus22135298
209CPPKLQATLDMQSGIdbPTM 3.0;PhosphoSitePlus;curated21044959; 16381945; 23193290; 22135298; 22817900
272EDVQALVSGKLALRYdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated17081983; 16381945; 23193290; 20068231; 18988627; 21081558;
284LRYAGRQTEALKCVAPhosphoSitePlus22135298
298AQASKNRSLADFEKAPhosphoSitePlus;curated22135298; 25627689
320LRDDPIISTHLAKLYPhosphoSitePlus22135298
396DEPPVDKTYEAALETPHOSIDA;PhosphoSitePlus21081558; 22135298
397EPPVDKTYEAALETIPHOSIDA;PhosphoSitePlus21081558; 22135298
Sequence
(Fasta)		MAAAAVVEFQ RAQSLLSTDR EASIDILHSI VKRDIQENDE EAVQVKEQSI LELGSLLAKT 60
GQAAELGGLL KYVRPFLNSI SKAKAARLVR SLLDLFLDME AATGQEVELC LECIEWAKSE 120
KRTFLRQALE ARLVSLYFDT KRYQEALHLG SQLLRELKKM DDKALLVEVQ LLESKTYHAL 180
SNLPKARAAL TSARTTANAI YCPPKLQATL DMQSGIIHAA EEKDWKTAYS YFYEAFEGYD 240
SIDSPKAITS LKYMLLCKIM LNTPEDVQAL VSGKLALRYA GRQTEALKCV AQASKNRSLA 300
DFEKALTDYR AELRDDPIIS THLAKLYDNL LEQNLIRVIE PFSRVQIEHI SSLIKLSKAD 360
VERKLSQMIL DKKFHGILDQ GEGVLIIFDE PPVDKTYEAA LETIQNMSKV VDSLYNKAKK 420
LT 423
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0647--Proteasome
KW-1185--Reference proteome
Interpro

IPR013143--PAM
IPR000717--PCI_dom
IPR011990--TPR-like_helical_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE
Pfam

PF01399--PCI
Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0022624--C:proteasome accessory complex
GO:0000502--C:proteasome complex
GO:0005838--C:proteasome regulatory particle
GO:0000186--P:activation of MAPKK activity
GO:0031145--P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0042590--P:antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0002479--P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002474--P:antigen processing and presentation of peptide antigen via MHC class I
GO:0006915--P:apoptotic process
GO:0007411--P:axon guidance
GO:0034641--P:cellular nitrogen compound metabolic process
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0010467--P:gene expression
GO:0045087--P:innate immune response
GO:0008286--P:insulin receptor signaling pathway
GO:0000165--P:MAPK cascade
GO:0000278--P:mitotic cell cycle
GO:0043066--P:negative regulation of apoptotic process
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0038061--P:NIK/NF-kappaB signaling
GO:0006595--P:polyamine metabolic process
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0012501--P:programmed cell death
GO:0043248--P:proteasome assembly
GO:0000209--P:protein polyubiquitination
GO:0007265--P:Ras protein signal transduction
GO:0042981--P:regulation of apoptotic process
GO:0006521--P:regulation of cellular amino acid metabolic process
GO:0043488--P:regulation of mRNA stability
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0007264--P:small GTPase mediated signal transduction
GO:0044281--P:small molecule metabolic process
GO:0048863--P:stem cell differentiation
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0050852--P:T cell receptor signaling pathway
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway
GO:0016032--P:viral process