dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000039
Uniprot Accession O00230; CORT_HUMAN; Q5T6G0; Q6UX11;
Genbank Protein ID NP_001293.3;
Genbank Nucleotide ID NM_001302.4;
Protein Name Cortistatin
Protein Synonyms/Alias
Gene Name CORT
Gene Synonyms/Alias UNQ307/PRO350;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
32GGPTGRDSEHMQEAAPhosphoSitePlus22135298
Sequence
(Fasta)		MPLSPGLLLL LLSGATATAA LPLEGGPTGR DSEHMQEAAG IRKSSLLTFL AWWFEWTSQA 60
SAGPLIGEEA REVARRQEGA PPQQSARRDR MPCRNFFWKT FSSCK 106
Keyword

KW-0165--Cleavage on pair of basic residues
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0372--Hormone
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
Interpro

IPR004250--Somatostatin
IPR018142--Somatostatin/Cortistatin_C
PROSITE
Pfam

PF03002--Somatostatin
Gene Ontology

GO:0005615--C:extracellular space
GO:0001664--F:G-protein coupled receptor binding
GO:0005184--F:neuropeptide hormone activity
GO:0007193--P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007268--P:synaptic transmission