| Tag |
Content |
| dbPAF ID |
dbPAF-0000038 |
| Uniprot Accession |
O00222; GRM8_HUMAN; A4D0Y3; B0FZ74; B0M0L0; O15493; O95945; O95946; Q3MIV9; Q52M02; Q6J165;
|
| Genbank Protein ID |
NP_000836.2; NP_001120795.1; XP_006716001.1; XP_011514393.1; XP_011514394.1;
|
| Genbank Nucleotide ID |
NM_000845.2; NM_001127323.1; XM_006715938.2; XM_011516091.1; XM_011516092.1;
|
| Protein Name |
Metabotropic glutamate receptor 8 |
| Protein Synonyms/Alias |
|
| Gene Name |
GRM8 |
| Gene Synonyms/Alias |
GPRC1H;MGLUR8; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.Functional Description
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MVCEGKRSAS CPCFFLLTAK FYWILTMMQR THSQEYAHSI RVDGDIILGG LFPVHAKGER 60
GVPCGELKKE KGIHRLEAML YAIDQINKDP DLLSNITLGV RILDTCSRDT YALEQSLTFV 120
QALIEKDASD VKCANGDPPI FTKPDKISGV IGAAASSVSI MVANILRLFK IPQISYASTA 180
PELSDNTRYD FFSRVVPPDS YQAQAMVDIV TALGWNYVST LASEGNYGES GVEAFTQISR 240
EIGGVCIAQS QKIPREPRPG EFEKIIKRLL ETPNARAVIM FANEDDIRRI LEAAKKLNQS 300
GHFLWIGSDS WGSKIAPVYQ QEEIAEGAVT ILPKRASIDG FDRYFRSRTL ANNRRNVWFA 360
EFWEENFGCK LGSHGKRNSH IKKCTGLERI ARDSSYEQEG KVQFVIDAVY SMAYALHNMH 420
KDLCPGYIGL CPRMSTIDGK ELLGYIRAVN FNGSAGTPVT FNENGDAPGR YDIFQYQITN 480
KSTEYKVIGH WTNQLHLKVE DMQWAHREHT HPASVCSLPC KPGERKKTVK GVPCCWHCER 540
CEGYNYQVDE LSCELCPLDQ RPNMNRTGCQ LIPIIKLEWH SPWAVVPVFV AILGIIATTF 600
VIVTFVRYND TPIVRASGRE LSYVLLTGIF LCYSITFLMI AAPDTIICSF RRVFLGLGMC 660
FSYAALLTKT NRIHRIFEQG KKSVTAPKFI SPASQLVITF SLISVQLLGV FVWFVVDPPH 720
IIIDYGEQRT LDPEKARGVL KCDISDLSLI CSLGYSILLM VTCTVYAIKT RGVPETFNEA 780
KPIGFTMYTT CIIWLAFIPI FFGTAQSAEK MYIQTTTLTV SMSLSASVSL GMLYMPKVYI 840
IIFHPEQNVQ KRKRSFKAVV TAATMQSKLI QKGNDRPNGE VKSELCESLE TNTSSTKTTY 900
ISYSNHSI
909Fasta Sequence
>O00222|GRM8|Homo sapiens(Human)
MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI
|
| Keyword |
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0297--G-protein coupled receptor
KW-0325--Glycoprotein
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0552--Olfaction
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0716--Sensory transduction
KW-0732--Signal
KW-0807--Transducer
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
|
| Interpro |
IPR001828--ANF_lig-bd_rcpt
IPR000337--GPCR_3
IPR011500--GPCR_3_9-Cys_dom
IPR017978--GPCR_3_C
IPR017979--GPCR_3_CS
IPR000162--GPCR_3_mtglu_rcpt
IPR000144--GPCR_3_mtglu_rcpt_8
IPR028082--Peripla_BP_I
|
| PROSITE |
PS00979--G_PROTEIN_RECEP_F3_1
PS00980--G_PROTEIN_RECEP_F3_2
PS00981--G_PROTEIN_RECEP_F3_3
PS50259--G_PROTEIN_RECEP_F3_4
|
| Pfam |
PF00003--7tm_3
PF01094--ANF_receptor
PF07562--NCD3G
|
| Gene Ontology |
GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0042734--C:presynaptic membrane
GO:0004930--F:G-protein coupled receptor activity
GO:0008066--F:glutamate receptor activity
GO:0001642--F:group III metabotropic glutamate receptor activity
GO:0007196--P:adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0030818--P:negative regulation of cAMP biosynthetic process
GO:0051966--P:regulation of synaptic transmission, glutamatergic
GO:0007608--P:sensory perception of smell
GO:0007601--P:visual perception
|
