dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000037
Uniprot Accession O00221; IKBE_HUMAN; Q5T9V9;
Genbank Protein ID NP_004547.2;
Genbank Nucleotide ID NM_004556.2;
Protein Name NF-kappa-B inhibitor epsilon
Protein Synonyms/Alias
Gene Name NFKBIE
Gene Synonyms/Alias IKBE;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
54RVRRPCWSGGAGRGGPhosphoSitePlus22135298
153GPDEAEESQYDSGIEPhosphoSitePlus;curated22135298; 22115753
155DEAEESQYDSGIESLdbPTM 3.0;PhosphoSitePlus20562096; 16381945; 23193290; 22135298
157AEESQYDSGIESLRSdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated22115753; 16381945; 23193290; 19060867; 22135298; 25627689;
161QYDSGIESLRSLRSLdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated19574224; 16381945; 23193290; 19060867; 22135298; 22115753
164SGIESLRSLRSLPESPhosphoSitePlus22135298
167ESLRSLRSLPESTSAcurated25850435
177ESTSAPASGPSDGSPPhosphoSitePlus22135298
183ASGPSDGSPQPCTHPPhosphoSitePlus;curated22135298; 25850435; 25627689; 23663014; 26074081
188DGSPQPCTHPPGPVKcurated25627689; 24961811
Sequence
(Fasta)		MNQRRSESRP GNHRLQAYAE PGKGDSGGAG PLSGSARRGR GGGGAIRVRR PCWSGGAGRG 60
GGPAWAVRLP TVTAGWTWPA LRTLSSLRAG PSEPHSPGRR PPRAGRPLCQ ADPQPGKAAR 120
RSLEPDPAQT GPRPARAAGM SEARKGPDEA EESQYDSGIE SLRSLRSLPE STSAPASGPS 180
DGSPQPCTHP PGPVKEPQEK EDADGERADS TYGSSSLTYT LSLLGGPEAE DPAPRLPLPH 240
VGALSPQQLE ALTYISEDGD TLVHLAVIHE APAVLLCCLA LLPQEVLDIQ NNLYQTALHL 300
AVHLDQPGAV RALVLKGASR ALQDRHGDTA LHVACQRQHL ACARCLLEGR PEPGRGTSHS 360
LDLQLQNWQG LACLHIATLQ KNQPLMELLL RNGADIDVQE GTSGKTALHL AVETQERGLV 420
QFLLQAGAQV DARMLNGCTP LHLAAGRGLM GISSTLCKAG ADSLLRNVED ETPQDLTEES 480
LVLLPFDDLK ISGKLLLCTD 501
Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
Pfam

PF00023--Ank
PF12796--Ank_2
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0042994--P:cytoplasmic sequestering of transcription factor
GO:0042942--P:D-serine transport