dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000036
Uniprot Accession O00220; TR10A_HUMAN; A8K5I4; Q53Y72; Q96E62;
Genbank Protein ID NP_003835.3;
Genbank Nucleotide ID NM_003844.3;
Protein Name Tumor necrosis factor receptor superfamily member 10A
Protein Synonyms/Alias Death receptor 4;TNF-related apoptosis-inducing ligand receptor 1;TRAIL receptor 1;TRAIL-R1;
Gene Name TNFRSF10A
Gene Synonyms/Alias APO2;DR4;TRAILR1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
83PRPAREASPRLRVHKdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated17081983; 16381945; 23193290; 21081558; 22135298; 19366988;
178KSDEEERSPCTTTRNPhosphoSitePlus;curated22135298; 25627689
424NKTGRNASIHTLLDAdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19651622; 16381945; 23193290; 18988627; 22135298; 23898821;
456VDSGKFIYLEDGTGSPhosphoSitePlus;curated22135298; 20873877
461FIYLEDGTGSAVSLEdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated17081983; 16381945; 23193290; 21081558; 22135298; 19366988;
463YLEDGTGSAVSLE--dbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 16381945; 23193290; 20068231; 22115753; 19651622;
466DGTGSAVSLE-----dbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 16381945; 23193290; 20068231; 22115753; 19651622;
Sequence
(Fasta)		MAPPPARVHL GAFLAVTPNP GSAASGTEAA AATPSKVWGS SAGRIEPRGG GRGALPTSMG 60
QHGPSARARA GRAPGPRPAR EASPRLRVHK TFKFVVVGVL LQVVPSSAAT IKLHDQSIGT 120
QQWEHSPLGE LCPPGSHRSE HPGACNRCTE GVGYTNASNN LFACLPCTAC KSDEEERSPC 180
TTTRNTACQC KPGTFRNDNS AEMCRKCSRG CPRGMVKVKD CTPWSDIECV HKESGNGHNI 240
WVILVVTLVV PLLLVAVLIV CCCIGSGCGG DPKCMDRVCF WRLGLLRGPG AEDNAHNEIL 300
SNADSLSTFV SEQQMESQEP ADLTGVTVQS PGEAQCLLGP AEAEGSQRRR LLVPANGADP 360
TETLMLFFDK FANIVPFDSW DQLMRQLDLT KNEIDVVRAG TAGPGDALYA MLMKWVNKTG 420
RNASIHTLLD ALERMEERHA REKIQDLLVD SGKFIYLEDG TGSAVSLE 469
Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR011029--DEATH-like_dom
IPR000488--Death_domain
IPR001368--TNFR/NGFR_Cys_rich_reg
IPR020465--TNFR_10
PROSITE

PS50017--DEATH_DOMAIN
PS00652--TNFR_NGFR_1
PS50050--TNFR_NGFR_2
Pfam

PF00531--Death
PF00020--TNFR_c6
Gene Ontology

GO:0009986--C:cell surface
GO:0016021--C:integral component of membrane
GO:0005887--C:integral component of plasma membrane
GO:0005622--C:intracellular
GO:0005886--C:plasma membrane
GO:0005035--F:death receptor activity
GO:0002020--F:protease binding
GO:0004872--F:receptor activity
GO:0045569--F:TRAIL binding
GO:0008134--F:transcription factor binding
GO:0005031--F:tumor necrosis factor-activated receptor activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0097296--P:activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0006915--P:apoptotic process
GO:0007166--P:cell surface receptor signaling pathway
GO:0071260--P:cellular response to mechanical stimulus
GO:0097191--P:extrinsic apoptotic signaling pathway
GO:0008625--P:extrinsic apoptotic signaling pathway via death domain receptors
GO:0006955--P:immune response
GO:0006954--P:inflammatory response
GO:0007275--P:multicellular organismal development
GO:0070266--P:necroptotic process
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0012501--P:programmed cell death
GO:0097300--P:programmed necrotic cell death
GO:0042127--P:regulation of cell proliferation
GO:1902041--P:regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0010939--P:regulation of necrotic cell death
GO:0032496--P:response to lipopolysaccharide
GO:0007165--P:signal transduction
GO:0036462--P:TRAIL-activated apoptotic signaling pathway
GO:0033209--P:tumor necrosis factor-mediated signaling pathway