| Tag |
Content |
| dbPAF ID |
dbPAF-0000035 |
| Uniprot Accession |
O00219; HYAS3_HUMAN; A8K5T5; Q8WTZ0; Q9NYP0;
|
| Genbank Protein ID |
NP_001186209.1; NP_005320.2; NP_619515.1; XP_005255978.1; XP_011521363.1;
|
| Genbank Nucleotide ID |
NM_001199280.1; NM_005329.2; NM_138612.2; XM_005255921.1; XM_011523061.1;
|
| Protein Name |
Hyaluronan synthase 3 |
| Protein Synonyms/Alias |
Hyaluronate synthase 3;Hyaluronic acid synthase 3;HA synthase 3; |
| Gene Name |
HAS3 |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity).Functional Description
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MPVQLTTALR VVGTSLFALA VLGGILAAYV TGYQFIHTEK HYLSFGLYGA ILGLHLLIQS 60
LFAFLEHRRM RRAGQALKLP SPRRGSVALC IAAYQEDPDY LRKCLRSAQR ISFPDLKVVM 120
VVDGNRQEDA YMLDIFHEVL GGTEQAGFFV WRSNFHEAGE GETEASLQEG MDRVRDVVRA 180
STFSCIMQKW GGKREVMYTA FKALGDSVDY IQVCDSDTVL DPACTIEMLR VLEEDPQVGG 240
VGGDVQILNK YDSWISFLSS VRYWMAFNVE RACQSYFGCV QCISGPLGMY RNSLLQQFLE 300
DWYHQKFLGS KCSFGDDRHL TNRVLSLGYR TKYTARSKCL TETPTKYLRW LNQQTRWSKS 360
YFREWLYNSL WFHKHHLWMT YESVVTGFFP FFLIATVIQL FYRGRIWNIL LFLLTVQLVG 420
IIKATYACFL RGNAEMIFMS LYSLLYMSSL LPAKIFAIAT INKSGWGTSG RKTIVVNFIG 480
LIPVSIWVAV LLGGLAYTAY CQDLFSETEL AFLVSGAILY GCYWVALLML YLAIIARRCG 540
KKPEQYSLAF AEV
554Fasta Sequence
>O00219|HAS3|Homo sapiens(Human)
MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARSKCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATVIQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFAIATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQDLFSETELAFLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV
|
| Keyword |
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0328--Glycosyltransferase
KW-0472--Membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
|
| Interpro |
IPR026108--HA_synthase_3
IPR026107--HAS/NodC
IPR029044--Nucleotide-diphossugar_trans
|
| PROSITE |
|
| Pfam |
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0036117--C:hyaluranon cable
GO:0016021--C:integral component of membrane
GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0050501--F:hyaluronan synthase activity
GO:0005975--P:carbohydrate metabolic process
GO:0007155--P:cell adhesion
GO:0085029--P:extracellular matrix assembly
GO:0045226--P:extracellular polysaccharide biosynthetic process
GO:0030203--P:glycosaminoglycan metabolic process
GO:0030213--P:hyaluronan biosynthetic process
GO:0030212--P:hyaluronan metabolic process
GO:1900106--P:positive regulation of hyaluranon cable assembly
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0044281--P:small molecule metabolic process
|
