| Tag |
Content |
| dbPAF ID |
dbPAF-0000034 |
| Uniprot Accession |
O00217; NDUS8_HUMAN; B2RB86; Q0VDA8;
|
| Genbank Protein ID |
NP_002487.1; XP_005274070.1; XP_005274071.1; XP_011543355.1;
|
| Genbank Nucleotide ID |
NM_002496.3; XM_005274013.1; XM_005274014.1; XM_011545053.1;
|
| Protein Name |
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial |
| Protein Synonyms/Alias |
|
| Gene Name |
NDUFS8 |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone.Functional Description
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone. |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MRCLTTPMLL RALAQAARAG PPGGRSLHSS AVAATYKYVN MQDPEMDMKS VTDRAARTLL 60
WTELFRGLGM TLSYLFREPA TINYPFEKGP LSPRFRGEHA LRRYPSGEER CIACKLCEAI 120
CPAQAITIEA EPRADGSRRT TRYDIDMTKC IYCGFCQEAC PVDAIVEGPN FEFSTETHEE 180
LLYNKEKLLN NGDKWEAEIA ANIQADYLYR
211Fasta Sequence
>O00217|NDUFS8|Homo sapiens(Human)
MRCLTTPMLLRALAQAARAGPPGGRSLHSSAVAATYKYVNMQDPEMDMKSVTDRAARTLLWTELFRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNGDKWEAEIAANIQADYLYR
|
| Keyword |
KW-0004--4Fe-4S
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0249--Electron transport
KW-0408--Iron
KW-0411--Iron-sulfur
KW-0431--Leigh syndrome
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0520--NAD
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0677--Repeat
KW-0679--Respiratory chain
KW-0809--Transit peptide
KW-0813--Transport
KW-0830--Ubiquinone
|
| Interpro |
IPR017896--4Fe4S_Fe-S-bd
IPR017900--4Fe4S_Fe_S_CS
IPR010226--NADH_quinone_OxRdtase_chainI
|
| PROSITE |
PS00198--4FE4S_FER_1
PS51379--4FE4S_FER_2
|
| Pfam |
PF12838--Fer4_7
|
| Gene Ontology |
GO:0005759--C:mitochondrial matrix
GO:0005747--C:mitochondrial respiratory chain complex I
GO:0005739--C:mitochondrion
GO:0051539--F:4 iron, 4 sulfur cluster binding
GO:0046872--F:metal ion binding
GO:0008137--F:NADH dehydrogenase (ubiquinone) activity
GO:0044237--P:cellular metabolic process
GO:0006120--P:mitochondrial electron transport, NADH to ubiquinone
GO:0032981--P:mitochondrial respiratory chain complex I assembly
GO:0022904--P:respiratory electron transport chain
GO:0006979--P:response to oxidative stress
GO:0044281--P:small molecule metabolic process
|
