| Tag |
Content |
| dbPAF ID |
dbPAF-0000031 |
| Uniprot Accession |
O00212; RHOD_HUMAN;
|
| Genbank Protein ID |
NP_055393.1;
|
| Genbank Nucleotide ID |
NM_014578.3;
|
| Protein Name |
Rho-related GTP-binding protein RhoD |
| Protein Synonyms/Alias |
Rho-related protein HP1;RhoHP1; |
| Gene Name |
RHOD |
| Gene Synonyms/Alias |
ARHD; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.Functional Description
Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MTAAQAAGEE APPGVRSVKV VLVGDGGCGK TSLLMVFADG AFPESYTPTV FERYMVNLQV 60
KGKPVHLHIW DTAGQDDYDR LRPLFYPDAS VLLLCFDVTS PNSFDNIFNR WYPEVNHFCK 120
KVPIIVVGCK TDLCKDKSLV NKLRRNGLEP VTYHRGQEMA RSVGAVAYLE CSARLHDNVH 180
AVFQEAAEVA LSSRGRNFWR RITQGFCVVT
211Fasta Sequence
>O00212|RHOD|Homo sapiens(Human)
MTAAQAAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPESYTPTVFERYMVNLQVKGKPVHLHIWDTAGQDDYDRLRPLFYPDASVLLLCFDVTSPNSFDNIFNRWYPEVNHFCKKVPIIVVGCKTDLCKDKSLVNKLRRNGLEPVTYHRGQEMARSVGAVAYLECSARLHDNVHAVFQEAAEVALSSRGRNFWRRITQGFCVVT
|
| Keyword |
KW-0002--3D-structure
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0967--Endosome
KW-0342--GTP-binding
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0488--Methylation
KW-0547--Nucleotide-binding
KW-0621--Polymorphism
KW-0636--Prenylation
KW-1185--Reference proteome
|
| Interpro |
IPR027417--P-loop_NTPase
IPR005225--Small_GTP-bd_dom
IPR001806--Small_GTPase
IPR003578--Small_GTPase_Rho
|
| PROSITE |
PS51420--RHO
|
| Pfam |
PF00071--Ras
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0010008--C:endosome membrane
GO:0005886--C:plasma membrane
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0051017--P:actin filament bundle assembly
GO:0048041--P:focal adhesion assembly
GO:0030032--P:lamellipodium assembly
GO:0045785--P:positive regulation of cell adhesion
GO:0030335--P:positive regulation of cell migration
GO:0006605--P:protein targeting
GO:2000249--P:regulation of actin cytoskeleton reorganization
GO:0051893--P:regulation of focal adhesion assembly
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0007266--P:Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
|
