KW-0002--3D-structure
KW-0913--Age-related macular degeneration
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0391--Immunity
KW-0395--Inflammatory response
KW-0399--Innate immunity
KW-0433--Leucine-rich repeat
KW-0472--Membrane
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix

IPR000483--Cys-rich_flank_reg_C
IPR001611--Leu-rich_rpt
IPR003591--Leu-rich_rpt_typical-subtyp
IPR000157--TIR_dom
IPR027168--TLR4

PS51450--LRR
PS50104--TIR

PF13855--LRR_8
PF01582--TIR

GO:0009986--C:cell surface
GO:0005737--C:cytoplasm
GO:0010008--C:endosome membrane
GO:0009897--C:external side of plasma membrane
GO:0005887--C:integral component of plasma membrane
GO:0031226--C:intrinsic component of plasma membrane
GO:0046696--C:lipopolysaccharide receptor complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0001530--F:lipopolysaccharide binding
GO:0001875--F:lipopolysaccharide receptor activity
GO:0004872--F:receptor activity
GO:0004888--F:transmembrane signaling receptor activity
GO:0097296--P:activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0000187--P:activation of MAPK activity
GO:0006915--P:apoptotic process
GO:0002322--P:B cell proliferation involved in immune response
GO:0071222--P:cellular response to lipopolysaccharide
GO:0071223--P:cellular response to lipoteichoic acid
GO:0071260--P:cellular response to mechanical stimulus
GO:0042742--P:defense response to bacterium
GO:0050829--P:defense response to Gram-negative bacterium
GO:0016046--P:detection of fungus
GO:0032497--P:detection of lipopolysaccharide
GO:0097191--P:extrinsic apoptotic signaling pathway
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0007252--P:I-kappaB phosphorylation
GO:0006955--P:immune response
GO:0045087--P:innate immune response
GO:0032609--P:interferon-gamma production
GO:0060729--P:intestinal epithelial structure maintenance
GO:0031663--P:lipopolysaccharide-mediated signaling pathway
GO:0042116--P:macrophage activation
GO:0002755--P:MyD88-dependent toll-like receptor signaling pathway
GO:0002756--P:MyD88-independent toll-like receptor signaling pathway
GO:0070373--P:negative regulation of ERK1 and ERK2 cascade
GO:0032689--P:negative regulation of interferon-gamma production
GO:0032700--P:negative regulation of interleukin-17 production
GO:0032707--P:negative regulation of interleukin-23 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0045671--P:negative regulation of osteoclast differentiation
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:0002537--P:nitric oxide production involved in inflammatory response
GO:0030890--P:positive regulation of B cell proliferation
GO:0032722--P:positive regulation of chemokine production
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0010628--P:positive regulation of gene expression
GO:0050729--P:positive regulation of inflammatory response
GO:0032727--P:positive regulation of interferon-alpha production
GO:0045359--P:positive regulation of interferon-beta biosynthetic process
GO:0032728--P:positive regulation of interferon-beta production
GO:0032729--P:positive regulation of interferon-gamma production
GO:0032732--P:positive regulation of interleukin-1 production
GO:0032733--P:positive regulation of interleukin-10 production
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032735--P:positive regulation of interleukin-12 production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0045416--P:positive regulation of interleukin-8 biosynthetic process
GO:0032757--P:positive regulation of interleukin-8 production
GO:0046330--P:positive regulation of JNK cascade
GO:0060907--P:positive regulation of macrophage cytokine production
GO:0045348--P:positive regulation of MHC class II biosynthetic process
GO:0042346--P:positive regulation of NF-kappaB import into nucleus
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045429--P:positive regulation of nitric oxide biosynthetic process
GO:0051770--P:positive regulation of nitric-oxide synthase biosynthetic process
GO:0070430--P:positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070434--P:positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0010572--P:positive regulation of platelet activation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042535--P:positive regulation of tumor necrosis factor biosynthetic process
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0012501--P:programmed cell death
GO:0050707--P:regulation of cytokine secretion
GO:0002730--P:regulation of dendritic cell cytokine production
GO:0032496--P:response to lipopolysaccharide
GO:0042088--P:T-helper 1 type immune response
GO:0034134--P:toll-like receptor 2 signaling pathway
GO:0034138--P:toll-like receptor 3 signaling pathway
GO:0034142--P:toll-like receptor 4 signaling pathway
GO:0002224--P:toll-like receptor signaling pathway
GO:0038123--P:toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124--P:toll-like receptor TLR6:TLR2 signaling pathway
GO:0035666--P:TRIF-dependent toll-like receptor signaling pathway