dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000029
Uniprot Accession O00204; ST2B1_HUMAN; O00205; O75814;
Genbank Protein ID NP_004596.2; NP_814444.1;
Genbank Nucleotide ID NM_004605.2; NM_177973.1;
Protein Name Sulfotransferase family cytosolic 2B member 1
Protein Synonyms/Alias
Gene Name SULT2B1
Gene Synonyms/Alias HSST2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.
Phosphorylation Sites
 dbPAF PTMs: 10
PositionPeptidesSourceReferences ( PMIDs )
16IPGLWDTYEDDISEIPhosphoSitePlus22135298
31SQKLPGEYFRYKGVPPhosphoSitePlus22135298
132HLPIQIFTKAFFSSKdbPTM 3.0;HPRD 9;PHOSIDA;curated20068231; 16381945; 23193290; 18988627; 21081558
137IFTKAFFSSKAKVIYPhosphoSitePlus22135298
253FSAMKANTMSNYTLLPhosphoSitePlus22135298
324GSPDPEPSPEPEPKPcurated25849741
347EREPRPNSSPSPSPGcurated23898821; 25849741
348REPRPNSSPSPSPGQdbPTM 3.0;PhosphoSitePlus;UniProt;curated21855633; 16381945; 23193290; 22135298; 24129246; 25849741
350PRPNSSPSPSPGQAScurated23898821; 25849741
352PNSSPSPSPGQASETcurated25849741
Sequence
(Fasta)		MDGPAEPQIP GLWDTYEDDI SEISQKLPGE YFRYKGVPFP VGLYSLESIS LAENTQDVRD 60
DDIFIITYPK SGTTWMIEII CLILKEGDPS WIRSVPIWER APWCETIVGA FSLPDQYSPR 120
LMSSHLPIQI FTKAFFSSKA KVIYMGRNPR DVVVSLYHYS KIAGQLKDPG TPDQFLRDFL 180
KGEVQFGSWF DHIKGWLRMK GKDNFLFITY EELQQDLQGS VERICGFLGR PLGKEALGSV 240
VAHSTFSAMK ANTMSNYTLL PPSLLDHRRG AFLRKGVCGD WKNHFTVAQS EAFDRAYRKQ 300
MRGMPTFPWD EDPEEDGSPD PEPSPEPEPK PSLEPNTSLE REPRPNSSPS PSPGQASETP 360
HPRPS 366
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0443--Lipid metabolism
KW-0492--Microsome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0753--Steroid metabolism
KW-0808--Transferase
Interpro

IPR027417--P-loop_NTPase
IPR000863--Sulfotransferase_dom
PROSITE
Pfam

PF00685--Sulfotransfer_1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0070062--C:extracellular exosome
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005634--C:nucleus
GO:0004027--F:alcohol sulfotransferase activity
GO:0050294--F:steroid sulfotransferase activity
GO:0050427--P:3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0044281--P:small molecule metabolic process
GO:0008202--P:steroid metabolic process
GO:0000103--P:sulfate assimilation
GO:0006805--P:xenobiotic metabolic process