dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000028
Uniprot Accession O00203; AP3B1_HUMAN; E5RJ68; O00580; Q7Z393; Q9HD66;
Genbank Protein ID NP_001258698.1; NP_003655.3;
Genbank Nucleotide ID NM_001271769.1; NM_003664.4;
Protein Name AP-3 complex subunit beta-1
Protein Synonyms/Alias Adaptor protein complex AP-3 subunit beta-1;Adaptor-related protein complex 3 subunit beta-1;Beta-3A-adaptin;Clathrin assembly protein complex 3 beta-1 large chain;
Gene Name AP3B1
Gene Synonyms/Alias ADTB3A;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Phosphorylation Sites
 dbPAF PTMs: 19
PositionPeptidesSourceReferences ( PMIDs )
29QEATSTISPSGAFGLcurated25627689; 26074081
89AVVKNVASKNIEIKKPhosphoSitePlus22135298
140ASALRVLSSIRVPIIPhosphoSitePlus22135298
141SALRVLSSIRVPIIVPhosphoSitePlus22135298
200EKLLKDKSTLVAGSVPhosphoSitePlus22135298
206KSTLVAGSVVMAFEEPhosphoSitePlus22135298
274EDNGKNFYESDDDQKdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated18669648; 16381945; 23193290; 18988627; 22135298; 25627689;
276NGKNFYESDDDQKEKdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18088087; 18669648; 18691976; 19413330; 16381945;
292DKKKKPYTMDPDHRLPhosphoSitePlus22135298
527KMAKSFTSEDDLVKLPhosphoSitePlus;curated22135298; 23186163
609KPAPLLESPFKDRDHdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18669648; 16381945; 23193290; 19276368; 19664994;
621RDHFQLGTLSHTLNIPhosphoSitePlus22135298
661IELAKEWTPAGKAKQdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 18988627; 22135298; 19366988;
750NSKAKGKSDSEDGEKdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;UniProt;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
752KAKGKSDSEDGEKENdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;UniProt;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
817TPLTKDVSLLDLDDFcurated26074081
839ALPTPALSPSLMADLcurated26074081
862SSVISVSTPAFVPTKPhosphoSitePlus22135298
1077LIINTEKTVIGSVLLPhosphoSitePlus22135298
Sequence
(Fasta)		MSSNSFPYNE QSGGGEATEL GQEATSTISP SGAFGLFSSD LKKNEDLKQM LESNKDSAKL 60
DAMKRIVGMI AKGKNASELF PAVVKNVASK NIEIKKLVYV YLVRYAEEQQ DLALLSISTF 120
QRALKDPNQL IRASALRVLS SIRVPIIVPI MMLAIKEASA DLSPYVRKNA AHAIQKLYSL 180
DPEQKEMLIE VIEKLLKDKS TLVAGSVVMA FEEVCPDRID LIHKNYRKLC NLLVDVEEWG 240
QVVIIHMLTR YARTQFVSPW KEGDELEDNG KNFYESDDDQ KEKTDKKKKP YTMDPDHRLL 300
IRNTKPLLQS RNAAVVMAVA QLYWHISPKS EAGIISKSLV RLLRSNREVQ YIVLQNIATM 360
SIQRKGMFEP YLKSFYVRST DPTMIKTLKL EILTNLANEA NISTLLREFQ TYVKSQDKQF 420
AAATIQTIGR CATNILEVTD TCLNGLVCLL SNRDEIVVAE SVVVIKKLLQ MQPAQHGEII 480
KHMAKLLDSI TVPVARASIL WLIGENCERV PKIAPDVLRK MAKSFTSEDD LVKLQILNLG 540
AKLYLTNSKQ TKLLTQYILN LGKYDQNYDI RDRTRFIRQL IVPNVKSGAL SKYAKKIFLA 600
QKPAPLLESP FKDRDHFQLG TLSHTLNIKA TGYLELSNWP EVAPDPSVRN VEVIELAKEW 660
TPAGKAKQEN SAKKFYSESE EEEDSSDSSS DSESESGSES GEQGESGEEG DSNEDSSEDS 720
SSEQDSESGR ESGLENKRTA KRNSKAKGKS DSEDGEKENE KSKTSDSSND ESSSIEDSSS 780
DSESESEPES ESESRRVTKE KEKKTKQDRT PLTKDVSLLD LDDFNPVSTP VALPTPALSP 840
SLMADLEGLH LSTSSSVISV STPAFVPTKT HVLLHRMSGK GLAAHYFFPR QPCIFGDKMV 900
SIQITLNNTT DRKIENIHIG EKKLPIGMKM HVFNPIDSLE PEGSITVSMG IDFCDSTQTA 960
SFQLCTKDDC FNVNIQPPVG ELLLPVAMSE KDFKKEQGVL TGMNETSAVI IAAPQNFTPS 1020
VIFQKVVNVA NVGAVPSGQD NIHRFAAKTV HSGSLMLVTV ELKEGSTAQL IINTEKTVIG 1080
SVLLRELKPV LSQG 1095
Keyword

KW-0015--Albinism
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0225--Disease mutation
KW-0333--Golgi apparatus
KW-0363--Hermansky-Pudlak syndrome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR026740--AP3_beta
IPR029394--AP3B1_Ser
IPR029390--AP3B_C
IPR026739--AP_beta
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR002553--Clathrin/coatomer_adapt-like_N
PROSITE
Pfam

PF01602--Adaptin_N
PF14796--AP3B1_C
PF14797--SEEEED
Gene Ontology

GO:0030123--C:AP-3 adaptor complex
GO:0030665--C:clathrin-coated vesicle membrane
GO:0005794--C:Golgi apparatus
GO:0005765--C:lysosomal membrane
GO:0016020--C:membrane
GO:0030742--F:GTP-dependent protein binding
GO:0019903--F:protein phosphatase binding
GO:0008089--P:anterograde axon cargo transport
GO:0048490--P:anterograde synaptic vesicle transport
GO:0048007--P:antigen processing and presentation, exogenous lipid antigen via MHC class Ib
GO:0007596--P:blood coagulation
GO:0006886--P:intracellular protein transport
GO:0032438--P:melanosome organization
GO:0051138--P:positive regulation of NK T cell differentiation
GO:0006622--P:protein targeting to lysosome