dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000024
Uniprot Accession O00189; AP4M1_HUMAN; D6W5U1; Q8WV65; Q9UHK9;
Genbank Protein ID NP_004713.2;
Genbank Nucleotide ID NM_004722.3;
Protein Name AP-4 complex subunit mu-1
Protein Synonyms/Alias AP-4 adaptor complex mu subunit;Adaptor-related protein complex 4 subunit mu-1;Mu subunit of AP-4;Mu-adaptin-related protein 2;mu-ARP2;Mu4-adaptin;mu4;
Gene Name AP4M1
Gene Synonyms/Alias MUARP2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Component of the AP-4 complex, a novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. Plays a role in the intracellular trafficking of APP from the trans-Golgi network (TGN) to endosomes, and thereby inhibits amyloidogenic processing of APP.
Phosphorylation Sites
 dbPAF PTMs: 7
PositionPeptidesSourceReferences ( PMIDs )
145AVVSKPFSLFDLSSVPhosphoSitePlus22135298
150PFSLFDLSSVGLFGAPhosphoSitePlus22135298
159VGLFGAETQQSKVAPPhosphoSitePlus22135298
162FGAETQQSKVAPSSAPhosphoSitePlus22135298
167QQSKVAPSSAASRPVcurated22817900; 18691976
171VAPSSAASRPVLSSRdbPTM 3.0;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated18691976; 16381945; 23193290; 21081558; 22135298; 19366988;
342PLPRGVVSLSQELSSdbPTM 3.017924679; 16381945; 23193290
Sequence
(Fasta)		MISQFFILSS KGDPLIYKDF RGDSGGRDVA ELFYRKLTGL PGDESPVVMH HHGRHFIHIR 60
HSGLYLVVTT SENVSPFSLL ELLSRLATLL GDYCGSLGEG TISRNVALVY ELLDEVLDYG 120
YVQTTSTEML RNFIQTEAVV SKPFSLFDLS SVGLFGAETQ QSKVAPSSAA SRPVLSSRSD 180
QSQKNEVFLD VVERLSVLIA SNGSLLKVDV QGEIRLKSFL PSGSEMRIGL TEEFCVGKSE 240
LRGYGPGIRV DEVSFHSSVN LDEFESHRIL RLQPPQGELT VMRYQLSDDL PSPLPFRLFP 300
SVQWDRGSGR LQVYLKLRCD LLSKSQALNV RLHLPLPRGV VSLSQELSSP EQKAELAEGA 360
LRWDLPRVQG GSQLSGLFQM DVPGPPGPPS HGLSTSASPL GLGPASLSFE LPRHTCSGLQ 420
VRFLRLAFRP CGNANPHKWV RHLSHSDAYV IRI 454
Keyword

KW-0002--3D-structure
KW-0168--Coated pit
KW-0181--Complete proteome
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR022775--AP_mu_sigma_su
IPR001392--Clathrin_mu
IPR018240--Clathrin_mu_CS
IPR011012--Longin-like_dom
IPR028565--MHD
PROSITE

PS00991--CLAT_ADAPTOR_M_2
PS51072--MHD
Pfam

PF00928--Adap_comp_sub
PF01217--Clat_adaptor_s
Gene Ontology

GO:0030119--C:AP-type membrane coat adaptor complex
GO:0030131--C:clathrin adaptor complex
GO:0005905--C:coated pit
GO:0031904--C:endosome lumen
GO:0070062--C:extracellular exosome
GO:0000138--C:Golgi trans cisterna
GO:0005802--C:trans-Golgi network
GO:0032588--C:trans-Golgi network membrane
GO:0005215--F:transporter activity
GO:0006895--P:Golgi to endosome transport
GO:0006886--P:intracellular protein transport
GO:0061024--P:membrane organization
GO:0006892--P:post-Golgi vesicle-mediated transport
GO:0016192--P:vesicle-mediated transport