| Tag |
Content |
| dbPAF ID |
dbPAF-0000023 |
| Uniprot Accession |
O00187; MASP2_HUMAN; A8K458; A8MWJ2; O75754; Q5TEQ5; Q5TER0; Q96QG4; Q9BZH0; Q9H498; Q9H499; Q9UBP3; Q9UC48; Q9ULC7; Q9UMV3; Q9Y270;
|
| Genbank Protein ID |
NP_006601.2; NP_631947.1;
|
| Genbank Nucleotide ID |
NM_006610.3; NM_139208.2;
|
| Protein Name |
Mannan-binding lectin serine protease 2 |
| Protein Synonyms/Alias |
MBL-associated serine protease 2;Mannose-binding protein-associated serine protease 2;MASP-2; |
| Gene Name |
MASP2 |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.Functional Description
Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. |
Phosphorylation Sites
|
dbPAF PTMs: 8 |
Sequence
(Fasta) | MRLLTLLGLL CGSVATPLGP KWPEPVFGRL ASPGFPGEYA NDQERRWTLT APPGYRLRLY 60
FTHFDLELSH LCEYDFVKLS SGAKVLATLC GQESTDTERA PGKDTFYSLG SSLDITFRSD 120
YSNEKPFTGF EAFYAAEDID ECQVAPGEAP TCDHHCHNHL GGFYCSCRAG YVLHRNKRTC 180
SALCSGQVFT QRSGELSSPE YPRPYPKLSS CTYSISLEEG FSVILDFVES FDVETHPETL 240
CPYDFLKIQT DREEHGPFCG KTLPHRIETK SNTVTITFVT DESGDHTGWK IHYTSTAQPC 300
PYPMAPPNGH VSPVQAKYIL KDSFSIFCET GYELLQGHLP LKSFTAVCQK DGSWDRPMPA 360
CSIVDCGPPD DLPSGRVEYI TGPGVTTYKA VIQYSCEETF YTMKVNDGKY VCEADGFWTS 420
SKGEKSLPVC EPVCGLSART TGGRIYGGQK AKPGDFPWQV LILGGTTAAG ALLYDNWVLT 480
AAHAVYEQKH DASALDIRMG TLKRLSPHYT QAWSEAVFIH EGYTHDAGFD NDIALIKLNN 540
KVVINSNITP ICLPRKEAES FMRTDDIGTA SGWGLTQRGF LARNLMYVDI PIVDHQKCTA 600
AYEKPPYPRG SVTANMLCAG LESGGKDSCR GDSGGALVFL DSETERWFVG GIVSWGSMNC 660
GEAGQYGVYT KVINYIPWIE NIISDF
687Fasta Sequence
>O00187|MASP2|Homo sapiens(Human)
MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENIISDF
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0068--Autocatalytic cleavage
KW-0106--Calcium
KW-0180--Complement pathway
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0245--EGF-like domain
KW-0378--Hydrolase
KW-0379--Hydroxylation
KW-0391--Immunity
KW-0399--Innate immunity
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0720--Serine protease
KW-0732--Signal
KW-0768--Sushi
|
| Interpro |
IPR000859--CUB_dom
IPR001881--EGF-like_Ca-bd_dom
IPR013032--EGF-like_CS
IPR000152--EGF-type_Asp/Asn_hydroxyl_site
IPR018097--EGF_Ca-bd_CS
IPR024175--Pept_S1A_C1r/C1S/mannan-bd
IPR018114--Peptidase_S1_AS
IPR009003--Peptidase_S1_PA
IPR001314--Peptidase_S1A
IPR000436--Sushi_SCR_CCP_dom
IPR001254--Trypsin_dom
|
| PROSITE |
PS00010--ASX_HYDROXYL
PS01180--CUB
PS01186--EGF_2
PS01187--EGF_CA
PS50923--SUSHI
PS50240--TRYPSIN_DOM
PS00135--TRYPSIN_SER
|
| Pfam |
PF00431--CUB
PF07645--EGF_CA
PF00084--Sushi
PF00089--Trypsin
|
| Gene Ontology |
GO:0070062--C:extracellular exosome
GO:0005576--C:extracellular region
GO:0005509--F:calcium ion binding
GO:0048306--F:calcium-dependent protein binding
GO:0001855--F:complement component C4b binding
GO:0008233--F:peptidase activity
GO:0004252--F:serine-type endopeptidase activity
GO:0006956--P:complement activation
GO:0006958--P:complement activation, classical pathway
GO:0001867--P:complement activation, lectin pathway
GO:0045087--P:innate immune response
|
