dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000022
Uniprot Accession O00186; STXB3_HUMAN; A8K269; A8K5K7; Q53FW1; Q86YJ3; Q9UPD7;
Genbank Protein ID NP_009200.2;
Genbank Nucleotide ID NM_007269.2;
Protein Name Syntaxin-binding protein 3
Protein Synonyms/Alias Platelet Sec1 protein;PSP;Protein unc-18 homolog 3;Unc18-3;Protein unc-18 homolog C;Unc-18C;
Gene Name STXBP3
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
103ASKSENKYKAAYIYFPhosphoSitePlus22135298
218VEKKLEDYYKIDEKScurated22817900
219EKKLEDYYKIDEKSLcurated22817900
312PKLMKEISSTKKATEdbPTM 3.0;curated18187866; 16381945; 23193290; 22817900
313KLMKEISSTKKATEGdbPTM 3.0;curated18187866; 16381945; 23193290; 22817900
314LMKEISSTKKATEGKdbPTM 3.0;curated18187866; 16381945; 23193290; 22817900
322KKATEGKTSLSALTQcurated25627689; 24961811
323KATEGKTSLSALTQLPhosphoSitePlus;curated22135298; 25627689
508CPAVWNGSGAVSARQPhosphoSitePlus;curated22135298; 25627689
512WNGSGAVSARQKPRAPhosphoSitePlus22135298
521RQKPRANYLEDRKNGdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated18083107; 18180459; 18707149; 20007894; 16381945; 23193290;
542VIGGITYSEVRCAYEPhosphoSitePlus22135298
556EVSQAHKSCEVIIGSPhosphoSitePlus22135298
587NKPKDKVSLIKDE--curated23911959
Sequence
(Fasta)		MAPPVAERGL KSVVWQKIKA TVFDDCKKEG EWKIMLLDEF TTKLLASCCK MTDLLEEGIT 60
VVENIYKNRE PVRQMKALYF ITPTSKSVDC FLHDFASKSE NKYKAAYIYF TDFCPDNLFN 120
KIKASCSKSI RRCKEINISF IPHESQVYTL DVPDAFYYCY SPDPGNAKGK DAIMETMADQ 180
IVTVCATLDE NPGVRYKSKP LDNASKLAQL VEKKLEDYYK IDEKSLIKGK THSQLLIIDR 240
GFDPVSTVLH ELTFQAMAYD LLPIENDTYK YKTDGKEKEA ILEEEDDLWV RIRHRHIAVV 300
LEEIPKLMKE ISSTKKATEG KTSLSALTQL MKKMPHFRKQ ITKQVVHLNL AEDCMNKFKL 360
NIEKLCKTEQ DLALGTDAEG QKVKDSMRVL LPVLLNKNHD NCDKIRAILL YIFSINGTTE 420
ENLDRLIQNV KIENESDMIR NWSYLGVPIV PQSQQGKPLR KDRSAEETFQ LSRWTPFIKD 480
IMEDAIDNRL DSKEWPYCSQ CPAVWNGSGA VSARQKPRAN YLEDRKNGSK LIVFVIGGIT 540
YSEVRCAYEV SQAHKSCEVI IGSTHVLTPK KLLDDIKMLN KPKDKVSLIK DE 593
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR027482--Sec-1-like_dom2
IPR001619--Sec1-like
PROSITE
Pfam

PF00995--Sec1
Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0016323--C:basolateral plasma membrane
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0031091--C:platelet alpha granule
GO:0042581--C:specific granule
GO:0070820--C:tertiary granule
GO:0019905--F:syntaxin binding
GO:0007596--P:blood coagulation
GO:0007420--P:brain development
GO:0015758--P:glucose transport
GO:0030073--P:insulin secretion
GO:0061024--P:membrane organization
GO:0045955--P:negative regulation of calcium ion-dependent exocytosis
GO:0043312--P:neutrophil degranulation
GO:0030168--P:platelet activation
GO:0070527--P:platelet aggregation
GO:0051291--P:protein heterooligomerization
GO:0022615--P:protein to membrane docking
GO:0032868--P:response to insulin
GO:0006904--P:vesicle docking involved in exocytosis