dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000019
Uniprot Accession O00178; GTPB1_HUMAN; Q6IC67;
Genbank Protein ID NP_004277.2;
Genbank Nucleotide ID NM_004286.4;
Protein Name GTP-binding protein 1
Protein Synonyms/Alias
Gene Name GTPBP1
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 34 (View all)
PositionPeptidesSourceReferences ( PMIDs )
6--MATERSRSAMDSPPhosphoSitePlus;curated22135298; 23090842
8MATERSRSAMDSPVPdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated22115753; 16381945; 23193290; 19651622; 18988627; 22135298;
12RSRSAMDSPVPASMFdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated19413330; 16381945; 23193290; 18669648; 22115753; 17081983;
17MDSPVPASMFAPEPSdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20230923; 16381945; 23193290; 18988627; 22135298; 22199227
24SMFAPEPSSPGAARAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated19413330; 16381945; 23193290; 18669648; 19362540; 19664995;
25MFAPEPSSPGAARAAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19413330; 16381945; 23193290; 19362540; 19415658;
44RLHGGFDSDCSEDGEdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18669648; 19413330; 19690332; 16381945; 23193290;
47GGFDSDCSEDGEALNdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18669648; 19413330; 19690332; 16381945; 23193290;
69TSKLVLVSPTSEQYDPhosphoSitePlus;curated22135298; 25850435
71KLVLVSPTSEQYDSLcurated25627689
72LVLVSPTSEQYDSLLcurated25850435
101IYVIGQGSDGTEYGLcurated23403867
104IGQGSDGTEYGLSEAcurated23403867
109DGTEYGLSEADMEAScurated23403867
116SEADMEASYATVKSMcurated23403867
174GNVDAGKSTLLGVLTPhosphoSitePlus22135298
175NVDAGKSTLLGVLTHPhosphoSitePlus22135298
181STLLGVLTHGELDNGPhosphoSitePlus22135298
205RHKHEIESGRTSSVGdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 22817900
259DLAGHEKYLKTTVFGPhosphoSitePlus22135298
Sequence
(Fasta)		MATERSRSAM DSPVPASMFA PEPSSPGAAR AAAAAARLHG GFDSDCSEDG EALNGEPELD 60
LTSKLVLVSP TSEQYDSLLR QMWERMDEGC GETIYVIGQG SDGTEYGLSE ADMEASYATV 120
KSMAEQIEAD VILLRERQEA GGRVRDYLVR KRVGDNDFLE VRVAVVGNVD AGKSTLLGVL 180
THGELDNGRG FARQKLFRHK HEIESGRTSS VGNDILGFDS EGNVVNKPDS HGGSLEWTKI 240
CEKSTKVITF IDLAGHEKYL KTTVFGMTGH LPDFCMLMVG SNAGIVGMTK EHLGLALALN 300
VPVFVVVTKI DMCPANILQE TLKLLQRLLK SPGCRKIPVL VQSKDDVIVT ASNFSSERMC 360
PIFQISNVTG ENLDLLKMFL NLLSPRTSYR EEEPAEFQID DTYSVPGVGT VVSGTTLRGL 420
IKLNDTLLLG PDPLGNFLSI AVKSIHRKRM PVKEVRGGQT ASFALKKIKR SSIRKGMVMV 480
SPRLNPQASW EFEAEILVLH HPTTISPRYQ AMVHCGSIRQ TATILSMDKD CLRTGDKATV 540
HFRFIKTPEY LHIDQRLVFR EGRTKAVGTI TKLLQTTNNS PMNSKPQQIK MQSTKKGPLT 600
KRDEGGPSGG PAVGAPPPGD EASSVGAGQP AASSNLQPQP KPSSGGRRRG GQRHKVKSQG 660
ACVTPASGC
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0342--GTP-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR027417--P-loop_NTPase
IPR000795--TF_GTP-bd_dom
IPR009000--Transl_B-barrel
IPR009001--Transl_elong_EF1A/Init_IF2_C
PROSITE

PS51722--G_TR_2
Pfam
Gene Ontology

GO:0000177--C:cytoplasmic exosome (RNase complex)
GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0016020--C:membrane
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0044822--F:poly(A) RNA binding
GO:0003743--F:translation initiation factor activity
GO:0006955--P:immune response
GO:0061014--P:positive regulation of mRNA catabolic process
GO:0007165--P:signal transduction
GO:0006413--P:translational initiation