dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000018
Uniprot Accession O00170; AIP_HUMAN; A0SZW3; A0SZW4; A0SZW5; A0SZW6; Q2M3Q2; Q99606;
Genbank Protein ID NP_001289888.1; NP_001289889.1; NP_003968.3;
Genbank Nucleotide ID NM_001302959.1; NM_001302960.1; NM_003977.3;
Protein Name AH receptor-interacting protein
Protein Synonyms/Alias
Gene Name AIP
Gene Synonyms/Alias XAP2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
43FHYRTLHSDDEGTVLdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated12361709; 16381945; 23193290; 18988627; 22135298; 23186163;
48LHSDDEGTVLDDSRAcurated20873877
53EGTVLDDSRARGKPMdbPTM 3.0;PhosphoSitePlus;curated12361709; 16381945; 23193290; 22135298; 22817900
79VWETIVCTMREGEIAdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298
104LYPLVAKSLRNIAVGPhosphoSitePlus22135298
131VAQMREHSSLGHADLdbPTM 3.0;PhosphoSitePlus;curated12361709; 16381945; 23193290; 22135298; 20873877; 22817900
132AQMREHSSLGHADLDdbPTM 3.0;PhosphoSitePlus;curated12361709; 16381945; 23193290; 22135298; 20873877; 22817900
159MEMLKVESPGTYQQDPhosphoSitePlus;curated22135298; 25627689; 26074081
162LKVESPGTYQQDPWAcurated25627689; 23186163
163KVESPGTYQQDPWAMdbPTM 3.0;PhosphoSitePlus;curated20562096; 16381945; 23193290; 22135298; 22817900
203KEAAAKYYDAIACLKdbPTM 3.0;PhosphoSitePlus20393185; 16381945; 23193290; 22135298
247CKLVVEEYYEVLDHCPhosphoSitePlus;curated22135298; 22817900
248KLVVEEYYEVLDHCSdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated15592455; 16381945; 23193290; 20562096; 18988627; 19060867;
329ARFRGIFSH------dbPTM 3.0;PhosphoSitePlus12361709; 16381945; 23193290; 22135298
Sequence
(Fasta)		MADIIARLRE DGIQKRVIQE GRGELPDFQD GTKATFHYRT LHSDDEGTVL DDSRARGKPM 60
ELIIGKKFKL PVWETIVCTM REGEIAQFLC DIKHVVLYPL VAKSLRNIAV GKDPLEGQRH 120
CCGVAQMREH SSLGHADLDA LQQNPQPLIF HMEMLKVESP GTYQQDPWAM TDEEKAKAVP 180
LIHQEGNRLY REGHVKEAAA KYYDAIACLK NLQMKEQPGS PEWIQLDQQI TPLLLNYCQC 240
KLVVEEYYEV LDHCSSILNK YDDNVKAYFK RGKAHAAVWN AQEAQADFAK VLELDPALAP 300
VVSRELQALE ARIRQKDEED KARFRGIFSH 331
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-1062--Cushing syndrome
KW-0963--Cytoplasm
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
Interpro

IPR031208--AIP
IPR001179--PPIase_FKBP_dom
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
PROSITE

PS50059--FKBP_PPIASE
PS50005--TPR
PS50293--TPR_REGION
Pfam

PF00254--FKBP_C
Gene Ontology

GO:0034751--C:aryl hydrocarbon receptor complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0036004--F:GAF domain binding
GO:0004871--F:signal transducer activity
GO:0003713--F:transcription coactivator activity
GO:0008134--F:transcription factor binding
GO:0051082--F:unfolded protein binding
GO:0051344--P:negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:0022417--P:protein maturation by protein folding
GO:0006626--P:protein targeting to mitochondrion
GO:0010738--P:regulation of protein kinase A signaling
GO:0007165--P:signal transduction
GO:0006805--P:xenobiotic metabolic process