dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000017
Uniprot Accession O00168; PLM_HUMAN; A8K196;
Genbank Protein ID NP_001265646.1; NP_001265647.1; NP_005022.2; NP_068702.1;
Genbank Nucleotide ID NM_001278717.1; NM_001278718.1; NM_005031.4; NM_021902.3;
Protein Name Phospholemman
Protein Synonyms/Alias FXYD domain-containing ion transport regulator 1;
Gene Name FXYD1
Gene Synonyms/Alias PLM;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed.
Phosphorylation Sites
 dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
79EPDEEEGTFRSSIRRdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated20166139; 16381945; 23193290; 18988627; 19060867; 22135298;
82EEEGTFRSSIRRLSTdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20166139; 20886841; 16381945; 23193290; 18988627; 22135298;
83EEGTFRSSIRRLSTRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated16155364; 10556585; 16381945; 23193290; 15621037; 16943195;
88RSSIRRLSTRRR---dbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus21868384; 16381945; 23193290; 15621037; 16608841; 16943195;
89SSIRRLSTRRR----dbPTM 3.0;PhosphoSitePlus21957166; 16381945; 23193290; 22135298
Sequence
(Fasta)		MASLGHILVF CVGLLTMAKA ESPKEHDPFT YDYQSLQIGG LVIAGILFIL GILIVLSRRC 60
RCKFNQQQRT GEPDEEEGTF RSSIRRLSTR RR 93
Keyword

KW-0002--3D-structure
KW-0868--Chloride
KW-0869--Chloride channel
KW-0181--Complete proteome
KW-0407--Ion channel
KW-0406--Ion transport
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR000272--Ion-transport_regulator_FXYD
PROSITE

PS01310--FXYD
Pfam

PF02038--ATP1G1_PLM_MAT8
Gene Ontology

GO:0005901--C:caveola
GO:0034707--C:chloride channel complex
GO:0005829--C:cytosol
GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0042383--C:sarcolemma
GO:0005890--C:sodium:potassium-exchanging ATPase complex
GO:0005254--F:chloride channel activity
GO:0044325--F:ion channel binding
GO:0017080--F:sodium channel regulator activity
GO:0007420--P:brain development
GO:1902476--P:chloride transmembrane transport
GO:0006821--P:chloride transport
GO:0051480--P:cytosolic calcium ion homeostasis
GO:0034220--P:ion transmembrane transport
GO:0006936--P:muscle contraction
GO:1903797--P:positive regulation of inorganic anion transmembrane transport
GO:0032892--P:positive regulation of organic acid transport
GO:1903278--P:positive regulation of sodium ion export from cell
GO:0086004--P:regulation of cardiac muscle cell contraction
GO:0086036--P:regulation of cardiac muscle cell membrane potential
GO:0008016--P:regulation of heart contraction
GO:2000649--P:regulation of sodium ion transmembrane transporter activity
GO:0055085--P:transmembrane transport