| Tag |
Content |
| dbPAF ID |
dbPAF-0000016 |
| Uniprot Accession |
O00167; EYA2_HUMAN; Q5JSW8; Q86U84; Q96CV6; Q96H97; Q99503; Q99812; Q9BWF6; Q9H4S3; Q9H4S9; Q9NPZ4; Q9UIX7;
|
| Genbank Protein ID |
NP_005235.3; NP_742108.2;
|
| Genbank Nucleotide ID |
NM_005244.4; NM_172110.3;
|
| Protein Name |
Eyes absent homolog 2 |
| Protein Synonyms/Alias |
|
| Gene Name |
EYA2 |
| Gene Synonyms/Alias |
EAB1; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed:12500905).Functional Description
Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed:12500905). |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MVELVISPSL TVNSDCLDKL KFNRADAAVW TLSDRQGITK SAPLRVSQLF SRSCPRVLPR 60
QPSTAMAAYG QTQYSAGIQQ ATPYTAYPPP AQAYGIPSYS IKTEDSLNHS PGQSGFLSYG 120
SSFSTSPTGQ SPYTYQMHGT TGFYQGGNGL GNAAGFGSVH QDYPSYPGFP QSQYPQYYGS 180
SYNPPYVPAS SICPSPLSTS TYVLQEASHN VPNQSSESLA GEYNTHNGPS TPAKEGDTDR 240
PHRASDGKLR GRSKRSSDPS PAGDNEIERV FVWDLDETII IFHSLLTGTF ASRYGKDTTT 300
SVRIGLMMEE MIFNLADTHL FFNDLEDCDQ IHVDDVSSDD NGQDLSTYNF SADGFHSSAP 360
GANLCLGSGV HGGVDWMRKL AFRYRRVKEM YNTYKNNVGG LIGTPKRETW LQLRAELEAL 420
TDLWLTHSLK ALNLINSRPN CVNVLVTTTQ LIPALAKVLL YGLGSVFPIE NIYSATKTGK 480
ESCFERIMQR FGRKAVYVVI GDGVEEEQGA KKHNMPFWRI SCHADLEALR HALELEYL
539Fasta Sequence
>O00167|EYA2|Homo sapiens(Human)
MVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFSRSCPRVLPRQPSTAMAAYGQTQYSAGIQQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTSPTGQSPYTYQMHGTTGFYQGGNGLGNAAGFGSVHQDYPSYPGFPQSQYPQYYGSSYNPPYVPASSICPSPLSTSTYVLQEASHNVPNQSSESLAGEYNTHNGPSTPAKEGDTDRPHRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL
|
| Keyword |
KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0227--DNA damage
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-0904--Protein phosphatase
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR028473--EYA2
IPR006545--EYA_dom
IPR028472--EYA_fam
IPR023214--HAD-like_dom
|
| PROSITE |
|
| Pfam |
PF00702--Hydrolase
|
| Gene Ontology |
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0000287--F:magnesium ion binding
GO:0004725--F:protein tyrosine phosphatase activity
GO:0006281--P:DNA repair
GO:0006302--P:double-strand break repair
GO:0097192--P:extrinsic apoptotic signaling pathway in absence of ligand
GO:0016576--P:histone dephosphorylation
GO:0007501--P:mesodermal cell fate specification
GO:0097345--P:mitochondrial outer membrane permeabilization
GO:0035335--P:peptidyl-tyrosine dephosphorylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0014706--P:striated muscle tissue development
GO:0006351--P:transcription, DNA-templated
|
