dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000015
Uniprot Accession O00165; HAX1_HUMAN; A8W4W9; A8W4X0; B4DUJ7; Q5VYD5; Q5VYD7; Q96AU4; Q9BS80;
Genbank Protein ID NP_001018238.1; NP_006109.2;
Genbank Nucleotide ID NM_001018837.1; NM_006118.3;
Protein Name HCLS1-associated protein X-1
Protein Synonyms/Alias HS1-associating protein X-1;HAX-1;HS1-binding protein 1;HSP1BP-1;
Gene Name HAX1
Gene Synonyms/Alias HS1BP1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Promotes cell survival. Potentiates GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. May regulate intracellular calcium pools.
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
53RGNPRFHSPQHPPEEPhosphoSitePlus22135298
66EEFGFGFSFSPGGGIPhosphoSitePlus22135298
68FGFGFSFSPGGGIRFPhosphoSitePlus22135298
124ERLREGQTLRDSMLKPhosphoSitePlus22135298
153ESDARSESPQPAPDWPhosphoSitePlus;curated22135298; 25627689; 23186163
162QPAPDWGSQRPFHRFPhosphoSitePlus;curated22135298; 23186163
181PMDPHPRTREDNDLDPhosphoSitePlus22135298
189REDNDLDSQVSQEGLPhosphoSitePlus;curated22135298; 23186163
192NDLDSQVSQEGLGPVPhosphoSitePlus;curated22135298; 23186163
210QPKSYFKSISVTKITPhosphoSitePlus22135298
212KSYFKSISVTKITKPdbPTM 3.0;PhosphoSitePlus21406692; 16381945; 23193290; 22135298
214YFKSISVTKITKPDGdbPTM 3.0;PhosphoSitePlus21406692; 16381945; 23193290; 22135298
255SPRGDPESPRPPALDdbPTM 3.0;PhosphoSitePlus21406692; 16381945; 23193290; 22135298
266PALDDAFSILDLFLGdbPTM 3.0;PhosphoSitePlus21406692; 16381945; 23193290; 22135298
Sequence
(Fasta)		MSLFDLFRGF FGFPGPRSHR DPFFGGMTRD EDDDEEEEEE GGSWGRGNPR FHSPQHPPEE 60
FGFGFSFSPG GGIRFHDNFG FDDLVRDFNS IFSDMGAWTL PSHPPELPGP ESETPGERLR 120
EGQTLRDSML KYPDSHQPRI FGGVLESDAR SESPQPAPDW GSQRPFHRFD DVWPMDPHPR 180
TREDNDLDSQ VSQEGLGPVL QPQPKSYFKS ISVTKITKPD GIVEERRTVV DSEGRTETTV 240
TRHEADSSPR GDPESPRPPA LDDAFSILDL FLGRWFRSR
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0496--Mitochondrion
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0703--Sarcoplasmic reticulum
Interpro

IPR017248--HAX-1
PROSITE
Pfam
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0016023--C:cytoplasmic membrane-bounded vesicle
GO:0005783--C:endoplasmic reticulum
GO:0030027--C:lamellipodium
GO:0005758--C:mitochondrial intermembrane space
GO:0005741--C:mitochondrial outer membrane
GO:0005739--C:mitochondrion
GO:0005635--C:nuclear envelope
GO:0031965--C:nuclear membrane
GO:0016529--C:sarcoplasmic reticulum
GO:0005667--C:transcription factor complex
GO:0019966--F:interleukin-1 binding
GO:0047485--F:protein N-terminus binding
GO:0071345--P:cellular response to cytokine stimulus
GO:0043066--P:negative regulation of apoptotic process
GO:2000251--P:positive regulation of actin cytoskeleton reorganization
GO:0030854--P:positive regulation of granulocyte differentiation
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0030833--P:regulation of actin filament polymerization
GO:0042981--P:regulation of apoptotic process
GO:1903146--P:regulation of mitophagy
GO:1903214--P:regulation of protein targeting to mitochondrion