dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000014
Uniprot Accession O00161; SNP23_HUMAN; O00162; Q13602; Q6IAE3;
Genbank Protein ID NP_003816.2; NP_570710.1; XP_011520432.1;
Genbank Nucleotide ID NM_003825.3; NM_130798.2; XM_011522130.1;
Protein Name Synaptosomal-associated protein 23
Protein Synonyms/Alias
Gene Name SNAP23
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.
Phosphorylation Sites
 dbPAF PTMs: 18
PositionPeptidesSourceReferences ( PMIDs )
5---MDNLSSEEIQQRdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated18578522; 20068231; 22115753; 16381945; 23193290; 18988627;
6--MDNLSSEEIQQRAdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated18691976; 16381945; 23193290; 18578522; 18988627; 21081558;
17QQRAHQITDESLESTPhosphoSitePlus;curated22135298; 25262027
20AHQITDESLESTRRIdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated18578522; 20068231; 20164059; 16381945; 23193290; 19651622;
23ITDESLESTRRILGLdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated12930825; 16381945; 23193290; 20068231; 18988627; 21081558;
24TDESLESTRRILGLAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated12930825; 16381945; 23193290; 19651622; 17081983; 18988627;
34ILGLAIESQDAGIKTdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated18578522; 21406692; 16381945; 23193290; 18988627; 19060867;
95NRTKNFESGKAYKTTdbPTM 3.0;PhosphoSitePlus;curated12930825; 16381945; 23193290; 22135298; 22817900
99NFESGKAYKTTWGDGPhosphoSitePlus22135298
102SGKAYKTTWGDGGENdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus19413330; 16381945; 23193290; 18988627; 19060867; 22135298
110WGDGGENSPCNVVSKdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18187866; 18669648; 19413330; 16381945; 23193290; 18578522;
123SKQPGPVTNGQLQQPcurated26074081
136QPTTGAASGGYIKRIPhosphoSitePlus;curated22135298; 25627689
139TGAASGGYIKRITNDdbPTM 3.0;PhosphoSitePlus;curated18083107; 18180459; 21394647; 16381945; 23193290; 22135298;
144GGYIKRITNDAREDEPhosphoSitePlus22135298
157DEMEENLTQVGSILGPhosphoSitePlus22135298
161ENLTQVGSILGNLKDdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;UniProt;curated12930825; 16381945; 23193290; 18578522; 20166139; 18988627;
211RAKKLIDS-------curated26074081
Sequence
(Fasta)		MDNLSSEEIQ QRAHQITDES LESTRRILGL AIESQDAGIK TITMLDEQKE QLNRIEEGLD 60
QINKDMRETE KTLTELNKCC GLCVCPCNRT KNFESGKAYK TTWGDGGENS PCNVVSKQPG 120
PVTNGQLQQP TTGAASGGYI KRITNDARED EMEENLTQVG SILGNLKDMA LNIGNEIDAQ 180
NPQIKRITDK ADTNRDRIDI ANARAKKLID S 212
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0770--Synapse
KW-0771--Synaptosome
KW-0813--Transport
Interpro

IPR000928--SNAP-25
IPR000727--T_SNARE_dom
PROSITE

PS50192--T_SNARE
Pfam

PF00835--SNAP-25
Gene Ontology

GO:0042582--C:azurophil granule
GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0042629--C:mast cell granule
GO:0043005--C:neuron projection
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0031201--C:SNARE complex
GO:0042581--C:specific granule
GO:0045202--C:synapse
GO:0005484--F:SNAP receptor activity
GO:0019905--F:syntaxin binding
GO:0006887--P:exocytosis
GO:0002553--P:histamine secretion by mast cell
GO:0061025--P:membrane fusion
GO:0061024--P:membrane organization
GO:0006892--P:post-Golgi vesicle-mediated transport
GO:0015031--P:protein transport
GO:0031629--P:synaptic vesicle fusion to presynaptic membrane
GO:0016082--P:synaptic vesicle priming
GO:0006903--P:vesicle targeting