dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000013
Uniprot Accession O00160; MYO1F_HUMAN; Q8WWN7;
Genbank Protein ID NP_036467.2;
Genbank Nucleotide ID NM_012335.3;
Protein Name Unconventional myosin-If
Protein Synonyms/Alias Myosin-Ie;
Gene Name MYO1F
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 29 (View all)
PositionPeptidesSourceReferences ( PMIDs )
45RKRFMDDYIFTYIGSPhosphoSitePlus22135298
49MDDYIFTYIGSVLISPhosphoSitePlus22135298
65NPFKQMPYFTDREIDPhosphoSitePlus22135298
122GKTVAAKYIMGYISKdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298
131MGYISKVSGGGEKVQdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
195SNFLLEKSRVVMQNEPhosphoSitePlus22135298
299GNYARVESVDLLAFPPhosphoSitePlus22135298
438IRWTPIQYFNNKVVCPhosphoSitePlus22135298
535LIELMQTSEQAFLRMdbPTM 3.0;PhosphoSitePlus19276368; 16381945; 23193290; 22135298
558DKKGRPSTAGSKIKKPhosphoSitePlus22135298
561GRPSTAGSKIKKQANPhosphoSitePlus22135298
607RVKHQVEYLGLKENIPhosphoSitePlus22135298
667VNMEPDQYQMGSTKVPhosphoSitePlus22135298
734KKERRRNSINRNFVGdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated17081983; 19369195; 16381945; 23193290; 20068231; 21406692;
743NRNFVGDYLGLEERPdbPTM 3.0;PhosphoSitePlus18083107; 16381945; 23193290; 22135298
769VDFADSVTKYDRRFKcurated26074081
771FADSVTKYDRRFKPIPhosphoSitePlus22135298
790ILTPKCVYVIGREKVdbPTM 3.0;PhosphoSitePlus19835603; 16381945; 23193290; 22135298
910VLKVGGRTLTVSVGDPhosphoSitePlus22135298
912KVGGRTLTVSVGDGLPhosphoSitePlus22135298
Sequence
(Fasta)		MGSKERFHWQ SHNVKQSGVD DMVLLPQITE DAIAANLRKR FMDDYIFTYI GSVLISVNPF 60
KQMPYFTDRE IDLYQGAAQY ENPPHIYALT DNMYRNMLID CENQCVIISG ESGAGKTVAA 120
KYIMGYISKV SGGGEKVQHV KDIILQSNPL LEAFGNAKTV RNNNSSRFGK YFEIQFSRGG 180
EPDGGKISNF LLEKSRVVMQ NENERNFHIY YQLLEGASQE QRQNLGLMTP DYYYYLNQSD 240
TYQVDGTDDR SDFGETLSAM QVIGIPPSIQ QLVLQLVAGI LHLGNISFCE DGNYARVESV 300
DLLAFPAYLL GIDSGRLQEK LTSRKMDSRW GGRSESINVT LNVEQAAYTR DALAKGLYAR 360
LFDFLVEAIN RAMQKPQEEY SIGVLDIYGF EIFQKNGFEQ FCINFVNEKL QQIFIELTLK 420
AEQEEYVQEG IRWTPIQYFN NKVVCDLIEN KLSPPGIMSV LDDVCATMHA TGGGADQTLL 480
QKLQAAVGTH EHFNSWSAGF VIHHYAGKVS YDVSGFCERN RDVLFSDLIE LMQTSEQAFL 540
RMLFPEKLDG DKKGRPSTAG SKIKKQANDL VATLMRCTPH YIRCIKPNET KRPRDWEENR 600
VKHQVEYLGL KENIRVRRAG FAYRRQFAKF LQRYAILTPE TWPRWRGDER QGVQHLLRAV 660
NMEPDQYQMG STKVFVKNPE SLFLLEEVRE RKFDGFARTI QKAWRRHVAV RKYEEMREEA 720
SNILLNKKER RRNSINRNFV GDYLGLEERP ELRQFLGKRE RVDFADSVTK YDRRFKPIKR 780
DLILTPKCVY VIGREKVKKG PEKGQVCEVL KKKVDIQALR GVSLSTRQDD FFILQEDAAD 840
SFLESVFKTE FVSLLCKRFE EATRRPLPLT FSDTLQFRVK KEGWGGGGTR SVTFSRGFGD 900
LAVLKVGGRT LTVSVGDGLP KSSKPTRKGM AKGKPRRSSQ APTRAAPAPP RGMDRNGVPP 960
SARGGPLPLE IMSGGGTHRP PRGPPSTSLG ASRRPRARPP SEHNTEFLNV PDQGMAGMQR 1020
KRSVGQRPVP GVGRPKPQPR THGPRCRALY QYVGQDVDEL SFNVNEVIEI LMEDPSGWWK 1080
GRLHGQEGLF PGNYVEKI 1099
Keyword

KW-0009--Actin-binding
KW-0067--ATP-binding
KW-0112--Calmodulin-binding
KW-0181--Complete proteome
KW-0505--Motor protein
KW-0518--Myosin
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR000048--IQ_motif_EF-hand-BS
IPR001609--Myosin_head_motor_dom
IPR010926--Myosin_TH1
IPR027417--P-loop_NTPase
IPR001452--SH3_domain
PROSITE

PS50096--IQ
PS51456--MYOSIN_MOTOR
PS50002--SH3
PS51757--TH1
Pfam

PF00063--Myosin_head
PF06017--Myosin_TH1
PF14604--SH3_9
Gene Ontology

GO:0030864--C:cortical actin cytoskeleton
GO:0031941--C:filamentous actin
GO:0016461--C:unconventional myosin complex
GO:0003779--F:actin binding
GO:0005524--F:ATP binding
GO:0003774--F:motor activity
GO:0050830--P:defense response to Gram-positive bacterium
GO:0007162--P:negative regulation of cell adhesion
GO:0043312--P:neutrophil degranulation
GO:0030335--P:positive regulation of cell migration
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0045088--P:regulation of innate immune response