dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000012
Uniprot Accession O00159; MYO1C_HUMAN; Q4LE56; Q6NVJ7; Q86Y95;
Genbank Protein ID NP_001074248.1; NP_001074419.1; NP_203693.3;
Genbank Nucleotide ID NM_001080779.1; NM_001080950.1; NM_033375.4;
Protein Name Unconventional myosin-Ic
Protein Synonyms/Alias Myosin I beta;MMI-beta;MMIb;
Gene Name MYO1C
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes.
Phosphorylation Sites
 dbPAF PTMs: 31 (View all)
PositionPeptidesSourceReferences ( PMIDs )
38GVRVTMESALTARDRdbPTM 3.0;HPRD 9;PhosphoSitePlus15302935; 16381945; 23193290; 18988627; 22135298
41VTMESALTARDRVGVdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298
78FRENLIYTYIGPVLVdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
79RENLIYTYIGPVLVSdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
124FAVADTVYRALRTERPhosphoSitePlus22135298
147GESGAGKTEATKRLLdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298
150GAGKTEATKRLLQFYdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298
263GLERNPQSYLYLVKGPhosphoSitePlus22135298
348LLSVEGSTLREALTHdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
376LNLEQAAYARDALAKPhosphoSitePlus22135298
408LASKDVESPSWRSTTdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18669648; 16381945; 23193290; 16964243; 19415658;
410SKDVESPSWRSTTVLdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627; 23403867; 23663014;
413VESPSWRSTTVLGLLdbPTM 3.018452278; 16381945; 23193290
415SPSWRSTTVLGLLDIdbPTM 3.0;HPRD 918452278; 16381945; 23193290; 18988627
432FEVFQHNSFEQFCINdbPTM 3.0;HPRD 918452278; 16381945; 23193290; 18988627
440FEQFCINYCNEKLQQdbPTM 3.018452278; 16381945; 23193290
473IAWEPVQYFNNKIICPhosphoSitePlus22135298
536ADQRTRKSLGRGEFRcurated23898821
589MSQCFDRSELSDKKRPhosphoSitePlus22135298
592CFDRSELSDKKRPETPhosphoSitePlus;curated22135298; 25627689; 23403867; 24961811
Sequence
(Fasta)		MALQVELVPT GEIIRVVHPH RPCKLALGSD GVRVTMESAL TARDRVGVQD FVLLENFTSE 60
AAFIENLRRR FRENLIYTYI GPVLVSVNPY RDLQIYSRQH MERYRGVSFY EVPPHLFAVA 120
DTVYRALRTE RRDQAVMISG ESGAGKTEAT KRLLQFYAET CPAPERGGAV RDRLLQSNPV 180
LEAFGNAKTL RNDNSSRFGK YMDVQFDFKG APVGGHILSY LLEKSRVVHQ NHGERNFHIF 240
YQLLEGGEEE TLRRLGLERN PQSYLYLVKG QCAKVSSIND KSDWKVVRKA LTVIDFTEDE 300
VEDLLSIVAS VLHLGNIHFA ANEESNAQVT TENQLKYLTR LLSVEGSTLR EALTHRKIIA 360
KGEELLSPLN LEQAAYARDA LAKAVYSRTF TWLVGKINRS LASKDVESPS WRSTTVLGLL 420
DIYGFEVFQH NSFEQFCINY CNEKLQQLFI ELTLKSEQEE YEAEGIAWEP VQYFNNKIIC 480
DLVEEKFKGI ISILDEECLR PGEATDLTFL EKLEDTVKHH PHFLTHKLAD QRTRKSLGRG 540
EFRLLHYAGE VTYSVTGFLD KNNDLLFRNL KETMCSSKNP IMSQCFDRSE LSDKKRPETV 600
ATQFKMSLLQ LVEILQSKEP AYVRCIKPND AKQPGRFDEV LIRHQVKYLG LLENLRVRRA 660
GFAYRRKYEA FLQRYKSLCP ETWPTWAGRP QDGVAVLVRH LGYKPEEYKM GRTKIFIRFP 720
KTLFATEDAL EVRRQSLATK IQAAWRGFHW RQKFLRVKRS AICIQSWWRG TLGRRKAAKR 780
KWAAQTIRRL IRGFVLRHAP RCPENAFFLD HVRTSFLLNL RRQLPQNVLD TSWPTPPPAL 840
REASELLREL CIKNMVWKYC RSISPEWKQQ LQQKAVASEI FKGKKDNYPQ SVPRLFISTR 900
LGTDEISPRV LQALGSEPIQ YAVPVVKYDR KGYKPRSRQL LLTPNAVVIV EDAKVKQRID 960
YANLTGISVS SLSDSLFVLH VQRADNKQKG DVVLQSDHVI ETLTKTALSA NRVNSININQ 1020
GSITFAGGPG RDGTIDFTPG SELLITKAKN GHLAVVAPRL NSR 1064
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0112--Calmodulin-binding
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0903--Direct protein sequencing
KW-0472--Membrane
KW-0488--Methylation
KW-0505--Motor protein
KW-0509--mRNA transport
KW-0518--Myosin
KW-0906--Nuclear pore complex
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0811--Translocation
KW-0813--Transport
Interpro

IPR000048--IQ_motif_EF-hand-BS
IPR001609--Myosin_head_motor_dom
IPR010926--Myosin_TH1
IPR027417--P-loop_NTPase
PROSITE

PS50096--IQ
PS51456--MYOSIN_MOTOR
PS51757--TH1
Pfam

PF00612--IQ
PF00063--Myosin_head
PF06017--Myosin_TH1
Gene Ontology

GO:0009925--C:basal plasma membrane
GO:0005903--C:brush border
GO:0005737--C:cytoplasm
GO:0016023--C:cytoplasmic membrane-bounded vesicle
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0031941--C:filamentous actin
GO:0016328--C:lateral plasma membrane
GO:0016020--C:membrane
GO:0045121--C:membrane raft
GO:0005902--C:microvillus
GO:0045160--C:myosin I complex
GO:0005643--C:nuclear pore
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0001726--C:ruffle
GO:0060171--C:stereocilium membrane
GO:0016461--C:unconventional myosin complex
GO:0030898--F:actin-dependent ATPase activity
GO:0005524--F:ATP binding
GO:0003774--F:motor activity
GO:0017160--F:Ral GTPase binding
GO:0005102--F:receptor binding
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087--P:innate immune response
GO:0061024--P:membrane organization
GO:0051028--P:mRNA transport
GO:0030335--P:positive regulation of cell migration
GO:0038089--P:positive regulation of cell migration by vascular endothelial growth factor signaling pathway
GO:0090314--P:positive regulation of protein targeting to membrane
GO:1900748--P:positive regulation of vascular endothelial growth factor signaling pathway
GO:0006605--P:protein targeting
GO:0006612--P:protein targeting to membrane
GO:2000810--P:regulation of bicellular tight junction assembly