dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000010
Uniprot Accession O00154; BACH_HUMAN; A8K0K7; A8K232; A8K6B8; A8K837; B3KQ12; O43703; Q53Y78; Q5JYL2; Q5JYL3; Q5JYL4; Q5JYL5; Q5JYL6; Q5TGR4; Q9UJM9; Q9Y539; Q9Y540;
Genbank Protein ID NP_009205.3; NP_863654.1; NP_863655.1; NP_863656.1;
Genbank Nucleotide ID NM_007274.3; NM_181864.2; NM_181865.2; NM_181866.2;
Protein Name Cytosolic acyl coenzyme A thioester hydrolase
Protein Synonyms/Alias Acyl-CoA thioesterase 7;Brain acyl-CoA hydrolase;BACH;CTE-IIa;CTE-II;Long chain acyl-CoA thioester hydrolase;
Gene Name ACOT7
Gene Synonyms/Alias BACH;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
159KKLTNKATLWYVPLSPhosphoSitePlus22135298
162TNKATLWYVPLSLKNPhosphoSitePlus22135298
166TLWYVPLSLKNVDKVPHOSIDA21081558
181LEVPPVVYSRQEQEEPhosphoSitePlus22135298
182EVPPVVYSRQEQEEEPhosphoSitePlus22135298
194EEEGRKRYEAQKLERPhosphoSitePlus;curated22135298; 26267517
268VAARHCKTNIVTASVdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
303MTFTSNKSMEIEVLVPhosphoSitePlus22135298
327QKRYRAASAFFTYVScurated25850435
Sequence
(Fasta)		MKLLARALRL CEFGRQASSR RLVAGQGCVG PRRGCCAPVQ VVGPRADLPP CGACITGRIM 60
RPDDANVAGN VHGGTILKMI EEAGAIISTR HCNSQNGERC VAALARVERT DFLSPMCIGE 120
VAHVSAEITY TSKHSVEVQV NVMSENILTG AKKLTNKATL WYVPLSLKNV DKVLEVPPVV 180
YSRQEQEEEG RKRYEAQKLE RMETKWRNGD IVQPVLNPEP NTVSYSQSSL IHLVGPSDCT 240
LHGFVHGGVT MKLMDEVAGI VAARHCKTNI VTASVDAINF HDKIRKGCVI TISGRMTFTS 300
NKSMEIEVLV DADPVVDSSQ KRYRAASAFF TYVSLSQEGR SLPVPQLVPE TEDEKKRFEE 360
GKGRYLQMKA KRQGHAEPQP 381
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0496--Mitochondrion
KW-1185--Reference proteome
KW-0677--Repeat
KW-0719--Serine esterase
Interpro

IPR029069--HotDog_dom
IPR006683--Thioestr_supf
PROSITE

PS51770--HOTDOG_ACOT
Pfam

PF03061--4HBT
Gene Ontology

GO:0044297--C:cell body
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0043005--C:neuron projection
GO:0005654--C:nucleoplasm
GO:0052689--F:carboxylic ester hydrolase activity
GO:0000062--F:fatty-acyl-CoA binding
GO:0036042--F:long-chain fatty acyl-CoA binding
GO:0016290--F:palmitoyl-CoA hydrolase activity
GO:0042803--F:protein homodimerization activity
GO:0044255--P:cellular lipid metabolic process
GO:0015937--P:coenzyme A biosynthetic process
GO:0009062--P:fatty acid catabolic process
GO:0035338--P:long-chain fatty-acyl-CoA biosynthetic process
GO:0036116--P:long-chain fatty-acyl-CoA catabolic process
GO:0051792--P:medium-chain fatty acid biosynthetic process
GO:0036114--P:medium-chain fatty-acyl-CoA catabolic process
GO:1900535--P:palmitic acid biosynthetic process
GO:0044281--P:small molecule metabolic process
GO:0019432--P:triglyceride biosynthetic process