dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000008
Uniprot Accession O00148; DX39A_HUMAN; B1Q2N1; Q8N5M0; Q9BVP6; Q9H5W0;
Genbank Protein ID NP_005795.2; XP_011525922.1;
Genbank Nucleotide ID NM_005804.3; XM_011527620.1;
Protein Name ATP-dependent RNA helicase DDX39A
Protein Synonyms/Alias DEAD box protein 39;Nuclear RNA helicase URH49;
Gene Name DDX39A
Gene Synonyms/Alias DDX39;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Isoform 1: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus.
Phosphorylation Sites
 dbPAF PTMs: 20
PositionPeptidesSourceReferences ( PMIDs )
13VENDLLDYDEEEEPQPhosphoSitePlus;curated22135298; 25850435; 25404012; 22817900
25EPQAPQESTPAPPKKdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627; 25627689; 25003641
26PQAPQESTPAPPKKDcurated25627689; 23186163
37PKKDIKGSYVSIHSSdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated19276368; 16381945; 23193290; 20068231; 18988627; 21081558;
38KKDIKGSYVSIHSSGdbPTM 3.0;PhosphoSitePlus;curated17360941; 21394647; 16381945; 23193290; 22135298; 20873877;
40DIKGSYVSIHSSGFRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 20068231; 20363803; 18988627;
43GSYVSIHSSGFRDFLPhosphoSitePlus;curated22135298; 20873877
44SYVSIHSSGFRDFLLcurated20873877
145YMPSVKVSVFFGGLSPhosphoSitePlus22135298
171CPHVVVGTPGRILALdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 16381945; 23193290; 19415658; 20068231; 20363803;
183LALVRNRSFSLKNVKPhosphoSitePlus;curated22135298; 23917254; 20873877; 22817900
185LVRNRSFSLKNVKHFcurated20873877
217VQEIFRLTPHEKQCMPhosphoSitePlus;curated22135298; 23186163
265LHGLQQYYVKLKDSEPhosphoSitePlus22135298
329QEERLSRYQQFKDFQcurated26074081
343QRRILVATNLFGRGMPhosphoSitePlus22135298
382ARAGRFGTKGLAITFPhosphoSitePlus22135298
391GLAITFVSDENDAKIPhosphoSitePlus22135298
421PEEIDISTYIEQSR-curated23663014
426ISTYIEQSR------dbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;UniProt;curated20068231; 21659604; 16381945; 23193290; 18988627; 21081558;
Sequence
(Fasta)		MAEQDVENDL LDYDEEEEPQ APQESTPAPP KKDIKGSYVS IHSSGFRDFL LKPELLRAIV 60
DCGFEHPSEV QHECIPQAIL GMDVLCQAKS GMGKTAVFVL ATLQQIEPVN GQVTVLVMCH 120
TRELAFQISK EYERFSKYMP SVKVSVFFGG LSIKKDEEVL KKNCPHVVVG TPGRILALVR 180
NRSFSLKNVK HFVLDECDKM LEQLDMRRDV QEIFRLTPHE KQCMMFSATL SKDIRPVCRK 240
FMQDPMEVFV DDETKLTLHG LQQYYVKLKD SEKNRKLFDL LDVLEFNQVI IFVKSVQRCM 300
ALAQLLVEQN FPAIAIHRGM AQEERLSRYQ QFKDFQRRIL VATNLFGRGM DIERVNIVFN 360
YDMPEDSDTY LHRVARAGRF GTKGLAITFV SDENDAKILN DVQDRFEVNV AELPEEIDIS 420
TYIEQSR 428
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0347--Helicase
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0694--RNA-binding
KW-0832--Ubl conjugation
Interpro

IPR011545--DEAD/DEAH_box_helicase_dom
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR014014--RNA_helicase_DEAD_Q_motif
PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS51195--Q_MOTIF
Pfam

PF00270--DEAD
PF00271--Helicase_C
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0005681--C:spliceosomal complex
GO:0005524--F:ATP binding
GO:0004004--F:ATP-dependent RNA helicase activity
GO:0044822--F:poly(A) RNA binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006406--P:mRNA export from nucleus
GO:0000398--P:mRNA splicing, via spliceosome
GO:0010468--P:regulation of gene expression
GO:0010501--P:RNA secondary structure unwinding