| Tag |
Content |
| dbPAF ID |
dbPAF-0000007 |
| Uniprot Accession |
O00142; KITM_HUMAN; B4DGJ7; B4DZK7; B7ZAB1; E9PH08; O15238;
|
| Genbank Protein ID |
NP_001166114.1; NP_001166115.1; NP_001258864.1; NP_001258979.1; NP_004605.4;
|
| Genbank Nucleotide ID |
NM_001172643.1; NM_001172644.1; NM_001271935.1; NM_001272050.1; NM_004614.4;
|
| Protein Name |
Thymidine kinase 2, mitochondrial |
| Protein Synonyms/Alias |
Mt-TK; |
| Gene Name |
TK2 |
| Gene Synonyms/Alias |
|
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Also phosphorylates anti-viral and anti-cancer nucleoside analogs.Functional Description
Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Also phosphorylates anti-viral and anti-cancer nucleoside analogs. |
Phosphorylation Sites
|
dbPAF PTMs: 7 |
Sequence
(Fasta) | MLLWPLRGWA ARALRCFGPG SRGSPASGPG PRRVQRRAWP PDKEQEKEKK SVICVEGNIA 60
SGKTTCLEFF SNATDVEVLT EPVSKWRNVR GHNPLGLMYH DASRWGLTLQ TYVQLTMLDR 120
HTRPQVSSVR LMERSIHSAR YIFVENLYRS GKMPEVDYVV LSEWFDWILR NMDVSVDLIV 180
YLRTNPETCY QRLKKRCREE EKVIPLEYLE AIHHLHEEWL IKGSLFPMAA PVLVIEADHH 240
MERMLELFEQ NRDRILTPEN RKHCP
266Fasta Sequence
>O00142|TK2|Homo sapiens(Human)
MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP
|
| Keyword |
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0237--DNA synthesis
KW-0418--Kinase
KW-0496--Mitochondrion
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0809--Transit peptide
|
| Interpro |
IPR002624--DCK/DGK
IPR031314--DNK_dom
IPR027417--P-loop_NTPase
|
| PROSITE |
|
| Pfam |
PF01712--dNK
|
| Gene Ontology |
GO:0005743--C:mitochondrial inner membrane
GO:0005759--C:mitochondrial matrix
GO:0005524--F:ATP binding
GO:0004137--F:deoxycytidine kinase activity
GO:0004797--F:thymidine kinase activity
GO:0046092--P:deoxycytidine metabolic process
GO:0009262--P:deoxyribonucleotide metabolic process
GO:0071897--P:DNA biosynthetic process
GO:0006264--P:mitochondrial DNA replication
GO:0006139--P:nucleobase-containing compound metabolic process
GO:0055086--P:nucleobase-containing small molecule metabolic process
GO:0006206--P:pyrimidine nucleobase metabolic process
GO:0043097--P:pyrimidine nucleoside salvage
GO:0044281--P:small molecule metabolic process
GO:0046104--P:thymidine metabolic process
|
