dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000005
Uniprot Accession O00139; KIF2A_HUMAN; A5YM42; A5YM54; B4DY54; D3DW97; E9PB70; Q7Z5I3; Q8N5Q7;
Genbank Protein ID NP_001091981.1; NP_001230881.1; NP_004511.2;
Genbank Nucleotide ID NM_001098511.2; NM_001243952.1; NM_004520.4;
Protein Name Kinesin-like protein KIF2A
Protein Synonyms/Alias Kinesin-2;hK2;
Gene Name KIF2A
Gene Synonyms/Alias KIF2;KNS2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.
Phosphorylation Sites
 dbPAF PTMs: 27 (View all)
PositionPeptidesSourceReferences ( PMIDs )
20IYVEIKRSDGRIHQAPhosphoSitePlus22135298
75PDEEIEPSPETPPPPdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;UniProt;curated19690332; 16381945; 23193290; 20068231; 18452278; 18988627;
78EIEPSPETPPPPASSdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated16565220; 19690332; 16381945; 23193290; 20058876; 18452278;
84ETPPPPASSAKVNKIcurated19690332
97KIVKNRRTVASIKNDPhosphoSitePlus;curated22135298; 23186163
100KNRRTVASIKNDPPSPhosphoSitePlus;curated22135298; 23917254
107SIKNDPPSRDNRVVGPhosphoSitePlus22135298
135SSAQQNGSVSDISPVPhosphoPep 2.0;PhosphoSitePlus;curated19060867; 22135298; 25627689; 23186163; 21857030
137AQQNGSVSDISPVQAdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated19276368; 16381945; 23193290; 19060867; 22135298; 23898821
140NGSVSDISPVQAAKKdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated16565220; 19007248; 16381945; 23193290; 19276368; 20886841;
157GPPSRRKSNCVKEVEPhosphoSitePlus;curated22135298; 26074081
195VDATNPNYEIMCMIRdbPTM 3.0;PhosphoSitePlus20736484; 16381945; 23193290; 22135298
210DFRGSLDYRPLTTADPhosphoSitePlus22135298
278NQTFRFDYAFDDSAPPhosphoSitePlus22135298
283FDYAFDDSAPNEMVYPHOSIDA21081558
290SAPNEMVYRFTARPLPHOSIDA21081558
484EGAEINKSLLALKECHPRD 9;PhosphoSitePlus;curated20068231; 18988627; 22135298; 23186163; 25003641; 22817900;
516LTQVLRDSFIGENSRPhosphoSitePlus;curated22135298; 23186163
546NTLNTLRYANRVKELcurated22817900
554ANRVKELTVDPTAAGPhosphoSitePlus22135298
Sequence
(Fasta)		MATANFGKIQ IGIYVEIKRS DGRIHQAMVT SLNEDNESVT VEWIENGDTK GKEIDLESIF 60
SLNPDLVPDE EIEPSPETPP PPASSAKVNK IVKNRRTVAS IKNDPPSRDN RVVGSARARP 120
SQFPEQSSSA QQNGSVSDIS PVQAAKKEFG PPSRRKSNCV KEVEKLQEKR EKRRLQQQEL 180
REKRAQDVDA TNPNYEIMCM IRDFRGSLDY RPLTTADPID EHRICVCVRK RPLNKKETQM 240
KDLDVITIPS KDVVMVHEPK QKVDLTRYLE NQTFRFDYAF DDSAPNEMVY RFTARPLVET 300
IFERGMATCF AYGQTGSGKT HTMGGDFSGK NQDCSKGIYA LAARDVFLML KKPNYKKLEL 360
QVYATFFEIY SGKVFDLLNR KTKLRVLEDG KQQVQVVGLQ EREVKCVEDV LKLIDIGNSC 420
RTSGQTSANA HSSRSHAVFQ IILRRKGKLH GKFSLIDLAG NERGADTSSA DRQTRLEGAE 480
INKSLLALKE CIRALGRNKP HTPFRASKLT QVLRDSFIGE NSRTCMIATI SPGMASCENT 540
LNTLRYANRV KELTVDPTAA GDVRPIMHHP PNQIDDLETQ WGVGSSPQRD DLKLLCEQNE 600
EEVSPQLFTF HEAVSQMVEM EEQVVEDHRA VFQESIRWLE DEKALLEMTE EVDYDVDSYA 660
TQLEAILEQK IDILTELRDK VKSFRAALQE EEQASKQINP KRPRAL 707
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0225--Disease mutation
KW-0493--Microtubule
KW-0498--Mitosis
KW-0505--Motor protein
KW-0524--Neurogenesis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR027640--Kinesin-like_fam
IPR019821--Kinesin_motor_CS
IPR001752--Kinesin_motor_dom
IPR027417--P-loop_NTPase
PROSITE

PS00411--KINESIN_MOTOR_1
PS50067--KINESIN_MOTOR_2
Pfam

PF00225--Kinesin
Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005871--C:kinesin complex
GO:0016020--C:membrane
GO:0005874--C:microtubule
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0097228--C:sperm principal piece
GO:0000922--C:spindle pole
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0003777--F:microtubule motor activity
GO:0003774--F:motor activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0007596--P:blood coagulation
GO:0030154--P:cell differentiation
GO:0051301--P:cell division
GO:0007019--P:microtubule depolymerization
GO:0007018--P:microtubule-based movement
GO:0000278--P:mitotic cell cycle
GO:0090307--P:mitotic spindle assembly
GO:0007052--P:mitotic spindle organization
GO:0007399--P:nervous system development
GO:0007264--P:small GTPase mediated signal transduction