dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000004
Uniprot Accession O00124; UBXN8_HUMAN; Q7Z6F2;
Genbank Protein ID NP_001269118.1; NP_001269128.1; NP_005662.1;
Genbank Nucleotide ID NM_001282189.1; NM_001282199.1; NM_005671.3;
Protein Name UBX domain-containing protein 8
Protein Synonyms/Alias Reproduction 8 protein;Rep-8 protein;UBX domain-containing protein 6;
Gene Name UBXN8
Gene Synonyms/Alias D8S2298E;REP8;UBXD6;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction.
Phosphorylation Sites
 dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
55LTLIISVTTSWLNSFPhosphoSitePlus22135298
96EAQGEKASRYIENVLdbPTM 3.0;PhosphoSitePlus18187866; 16381945; 23193290; 22135298
98QGEKASRYIENVLKPdbPTM 3.0;PhosphoSitePlus18187866; 16381945; 23193290; 22135298
144DEGTSQTSFETSNREcurated25627689
163QNLPKPLTEFPSPAEdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
167KPLTEFPSPAEQPTCdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 18691976; 16381945; 23193290; 18988627; 21081558;
Sequence
(Fasta)		MASRGVVGIF FLSAVPLVCL ELRRGIPDIG IKDFLLLCGR ILLLLALLTL IISVTTSWLN 60
SFKSPQVYLK EEEEKNEKRQ KLVRKKQQEA QGEKASRYIE NVLKPHQEMK LRKLEERFYQ 120
MTGEAWKLSS GHKLGGDEGT SQTSFETSNR EAAKSQNLPK PLTEFPSPAE QPTCKEIPDL 180
PEEPSQTAEE VVTVALRCPS GNVLRRRFLK SYSSQVLFDW MTRIGYHISL YSLSTSFPRR 240
PLAVEGGQSL EDIGITVDTV LILEEKEQTN 271
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom
IPR017247--UBXN8
PROSITE

PS50033--UBX
Pfam

PF00789--UBX
Gene Ontology

GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0030433--P:ER-associated ubiquitin-dependent protein catabolic process
GO:0007338--P:single fertilization