dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0000003
Uniprot Accession O00116; ADAS_HUMAN; A5D8U9; Q2TU35;
Genbank Protein ID NP_003650.1;
Genbank Nucleotide ID NM_003659.3;
Protein Name Alkyldihydroxyacetonephosphate synthase, peroxisomal
Protein Synonyms/Alias
Gene Name AGPS
Gene Synonyms/Alias AAG5;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.
Phosphorylation Sites
 dbPAF PTMs: 18
PositionPeptidesSourceReferences ( PMIDs )
11AAAAAGGTGLGAGASdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
18TGLGAGASYGSAADRcurated20068231
42GRRLRVLSGHLLGRPPhosphoSitePlus;curated22135298; 23917254
65CKARRAASAATAAPTdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated19276368; 16381945; 23193290; 19060867; 22135298; 24275569;
68RRAASAATAAPTATPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated18669648; 16381945; 23193290; 19276368; 20068231; 18988627;
72SAATAAPTATPAAQEdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 25627689;
74ATAAPTATPAAQESGPhosphoSitePlus;UniProt;curated22135298; 24275569; 25850435; 25627689; 23898821; 24961811
80ATPAAQESGTIPKKRcurated25850435
82PAAQESGTIPKKRQEcurated25850435
127LSGMGLPTFKEWIQNdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 22817900
149HKTTSKASLNPSDTPcurated25850435
155ASLNPSDTPPSVVNEPhosphoSitePlus;curated22135298; 25850435
257DETRTIISLDTSQMNPhosphoSitePlus22135298
261TIISLDTSQMNRILWPhosphoSitePlus22135298
326SGMKKNIYGNIEDLVPHOSIDA;PhosphoSitePlus21081558; 22135298
387KIRPVPEYQKYGSVAPhosphoSitePlus22135298
589AFNYRGISDPLTVFEcurated23663014
645MLKSVKEYVDPNNIFdbPTM 3.0;PhosphoSitePlus;curated22115753; 16381945; 23193290; 22135298; 24260401
Sequence
(Fasta)		MAEAAAAAGG TGLGAGASYG SAADRDRDPD PDRAGRRLRV LSGHLLGRPR EALSTNECKA 60
RRAASAATAA PTATPAAQES GTIPKKRQEV MKWNGWGYND SKFIFNKKGQ IELTGKRYPL 120
SGMGLPTFKE WIQNTLGVNV EHKTTSKASL NPSDTPPSVV NEDFLHDLKE TNISYSQEAD 180
DRVFRAHGHC LHEIFLLREG MFERIPDIVL WPTCHDDVVK IVNLACKYNL CIIPIGGGTS 240
VSYGLMCPAD ETRTIISLDT SQMNRILWVD ENNLTAHVEA GITGQELERQ LKESGYCTGH 300
EPDSLEFSTV GGWVSTRASG MKKNIYGNIE DLVVHIKMVT PRGIIEKSCQ GPRMSTGPDI 360
HHFIMGSEGT LGVITEATIK IRPVPEYQKY GSVAFPNFEQ GVACLREIAK QRCAPASIRL 420
MDNKQFQFGH ALKPQVSSIF TSFLDGLKKF YITKFKGFDP NQLSVATLLF EGDREKVLQH 480
EKQVYDIAAK FGGLAAGEDN GQRGYLLTYV IAYIRDLALE YYVLGESFET SAPWDRVVDL 540
CRNVKERITR ECKEKGVQFA PFSTCRVTQT YDAGACIYFY FAFNYRGISD PLTVFEQTEA 600
AAREEILANG GSLSHHHGVG KLRKQWLKES ISDVGFGMLK SVKEYVDPNN IFGNRNLL 659
Keyword

KW-0007--Acetylation
KW-0898--Cataract
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0242--Dwarfism
KW-0274--FAD
KW-0285--Flavoprotein
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0576--Peroxisome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0685--Rhizomelic chondrodysplasia punctata
KW-0808--Transferase
KW-0809--Transit peptide
Interpro

IPR025650--Alkyl-DHAP_Synthase
IPR016169--CO_DH_flavot_FAD-bd_sub2
IPR016166--FAD-bd_2
IPR016167--FAD-bd_2_sub1
IPR016164--FAD-linked_Oxase-like_C
IPR004113--FAD-linked_oxidase_C
IPR006094--Oxid_FAD_bind_N
PROSITE

PS51387--FAD_PCMH
Pfam

PF02913--FAD-oxidase_C
PF01565--FAD_binding_4
Gene Ontology

GO:0043231--C:intracellular membrane-bounded organelle
GO:0016020--C:membrane
GO:0005739--C:mitochondrion
GO:0005730--C:nucleolus
GO:0005782--C:peroxisomal matrix
GO:0005778--C:peroxisomal membrane
GO:0005777--C:peroxisome
GO:0008609--F:alkylglycerone-phosphate synthase activity
GO:0071949--F:FAD binding
GO:0016614--F:oxidoreductase activity, acting on CH-OH group of donors
GO:0044255--P:cellular lipid metabolic process
GO:0008611--P:ether lipid biosynthetic process
GO:0008610--P:lipid biosynthetic process
GO:0044281--P:small molecule metabolic process