dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0000002 |
| Uniprot Accession | O00115; DNS2A_HUMAN; B2RD06; B7Z4K6; O43910; |
| Genbank Protein ID | NP_001366.1; |
| Genbank Nucleotide ID | NM_001375.2; |
| Protein Name | Deoxyribonuclease-2-alpha |
| Protein Synonyms/Alias | Acid DNase;Deoxyribonuclease II alpha;DNase II alpha;Lysosomal DNase II;R31240_2; |
| Gene Name | DNASE2 |
| Gene Synonyms/Alias | DNASE2A;DNL2; |
| Organism | Homo sapiens(Human) |
| NCBI Taxa ID | 9606 |
| Functional Description (View all) |
Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells. |
| Phosphorylation Sites |
dbPAF PTMs: 5 |
| Sequence (Fasta) | MIPLLLAALL CVPAGALTCY GDSGQPVDWF VVYKLPALRG SGEAAQRGLQ YKYLDESSGG 60 WRDGRALINS PEGAVGRSLQ PLYRSNTSQL AFLLYNDQPP QPSKAQDSSM RGHTKGVLLL 120 DHDGGFWLVH SVPNFPPPAS SAAYSWPHSA CTYGQTLLCV SFPFAQFSKM GKQLTYTYPW 180 VYNYQLEGIF AQEFPDLENV VKGHHVSQEP WNSSITLTSQ AGAVFQSFAK FSKFGDDLYS 240 GWLAAALGTN LQVQFWHKTV GILPSNCSDI WQVLNVNQIA FPGPAGPSFN STEDHSKWCV 300 SPKGPWTCVG DMNRNQGEEQ RGGGTLCAQL PALWKAFQPL VKNYQPCNGM ARKPSRAYKI 360 361 |
| Keyword | KW-0025--Alternative splicing |
| Interpro | IPR004947--DNase_II |
| PROSITE | |
| Pfam | PF03265--DNase_II |
| Gene Ontology | GO:0070062--C:extracellular exosome |